Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with a relapsed or refractory aggressive B-cell lymphoma, specifically diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, or a large B-cell lymphoma that developed from another condition.
• People whose lymphoma has come back or stopped responding to treatment, fitting into one of two groups:
  • Group 1: People who have had 2 or more prior treatment courses (including both a targeted antibody therapy and a chemotherapy type called anthracycline) and whose disease has progressed after the last treatment — OR people whose lymphoma came back or did not respond well enough to their first course of treatment.
  • Group 2: People whose PET-CT scan still shows active disease after 2 cycles of initial treatment, or whose remaining disease has been confirmed by biopsy after initial therapy.
• People aged 18 to 65 years old.
• People who are generally able to care for themselves and carry out daily activities, with only limited restrictions (confirm with trial site for the specific activity level required).
• People whose blood cell counts meet minimum levels at screening — unless low counts are caused by lymphoma in the bone marrow (confirm exact values with trial site).
• People whose liver and kidney function results fall within the levels required at screening (confirm exact values with trial site).
• People whose heart pumping function is within the normal range, as measured by an ultrasound of the heart.
• People whose blood oxygen level is above 92% while breathing normal air.
• People whose doctor estimates they have a life expectancy of at least 3 months.

Who may not be able to join:

• People with lymphoma that started in the brain or spinal cord (primary central nervous system lymphoma).
• People who have previously had a stem cell transplant, either using their own cells or donated cells.
• People with an active hepatitis B or hepatitis C infection detected in their blood.
• People with serious ongoing conditions that are not well controlled, such as active infections, heart or blood vessel problems, blood clotting disorders, or connective tissue diseases.
• People with a history of epilepsy or other conditions affecting the brain or nervous system.
• People who are pregnant or currently breastfeeding.
• People with an HIV infection.
• People who have had another type of cancer, unless they have been free of that cancer for 5 or more years — or unless the previous cancer was a non-melanoma skin cancer, a localised skin cancer, or cervical carcinoma in situ that has been treated and cured.
• People whom the trial investigators determine are not suitable for other reasons (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.