Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who are not suitable for a stem cell transplant using their own cells
• People who have given written consent to participate in the study
• People whose lymphoma has been confirmed by a lab test to be a specific type called CD79b-positive DLBCL (this includes certain related subtypes)
• People who have received one prior course of treatment that included both an anti-CD20 antibody medicine (such as rituximab) and a chemotherapy drug from the anthracycline family, and no more than this one course of treatment
• People whose lymphoma came back after responding to first-line treatment, or whose lymphoma did not fully respond to first-line treatment
• People who are reasonably well and able to carry out daily activities, with a life expectancy of more than 12 weeks (confirm with trial site)
• People who have at least one area of lymphoma that can be measured on a scan or clinical examination, meeting specific size requirements
• People whose blood counts, liver, kidneys, lungs, and heart are all functioning at an acceptable level as determined by test results
• People of childbearing potential who are willing to use highly effective contraception during the study and for 120 days after the last treatment dose

Who may not be able to join:

• People who have conditions — medical, personal, family, or practical — that would make it difficult to follow the study requirements, as judged by the study doctor
• People who have HIV infection or test positive for HIV
• People with active or uncontrolled viral infections such as active herpes, active hepatitis B, or active hepatitis C (people who are long-term hepatitis B carriers with very low virus levels may still be considered; people with a positive hepatitis C antibody test will need further testing before a decision is made — confirm with trial site)
• People whose lymphoma has spread to the brain or spinal cord and is not fully under control (people who had brain involvement at the original diagnosis but achieved and maintained complete remission may still be considered — confirm with trial site)
• People who have previously been treated with the chemotherapy drugs oxaliplatin or gemcitabine
• People who are pregnant or breastfeeding
• People with other serious illnesses or medical conditions that would make participation unsafe

Important: Always verify eligibility with the trial site directly before applying.