Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 80 years of age who, before their stroke, had little to no disability (specifically, a disability score of 0–1 for those aged 18–70, or a score of 0 — meaning no disability at all — for those over 70).
• People who have shown signs of an acute ischemic stroke (a stroke caused by a blocked blood vessel) that started between 24 and 72 hours before being assessed (confirm with trial site for specific timing rules).
• People whose stroke symptoms are rated as moderately severe or worse on a standard medical scale (a score of 8 or higher on the NIHSS stroke severity scale).
• People whose brain scans show a blockage in a major blood vessel at the front of the brain, identified by automated imaging software or a specialised scan called a CT angiogram (CTA), when available.
• People whose brain scans show that the area of permanent brain damage is not too large (70 millilitres or less, or an ASPECTS score of 6 or higher on brain imaging).
• People for whom a procedure to access an artery can be performed within 72 hours of stroke onset and within 90 minutes of their initial CT scan.
• People who can be enrolled in the trial within 72 hours of their stroke onset.
• People who are able to give signed consent, or whose legally authorised representative is able to give consent on their behalf (emergency consent procedures may apply in some cases if approved by local ethics committees and regulations).

Who may not be able to join:

• People who are pregnant, or women of childbearing age whose pregnancy test (urine or blood) comes back positive.
• People with a known severe allergic reaction (more than a skin rash) to contrast dye used in medical imaging, which cannot be controlled with medication.
• People with very high blood pressure that remains dangerously elevated even after medication (systolic above 185 mmHg or diastolic above 110 mmHg).
• People whose brain scans show certain serious conditions, such as a shift of brain structures to one side, signs of bleeding in the brain, or significant swelling pressing on the brain's fluid-filled spaces.
• People who have had strokes on both sides of the brain.
• People who had a previous clot removal procedure attempted less than 6 hours before.
• People who received clot-dissolving medication more than 4.5 hours after their stroke symptoms began.
• People with a tumour inside the skull.
• People who, before their stroke, were not expected to live more than 90 days.
• People already participating in another clinical trial that could affect the results of this study.
• People whose stroke is suspected to be caused by an infected clot or a bacterial heart infection.
• People with a pre-existing neurological or psychiatric condition (such as dementia treated with certain medications) that would make it difficult to assess stroke-related outcomes.
• People for whom, in the opinion of the treating doctor at the trial site, the procedure would be unsafe or unsuitable for any other reason.

Important: Always verify eligibility with the trial site directly before applying.