Macular Degeneration Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 50 and 85 years old at the time of signing up for the trial
• You have been diagnosed with a type of age-related macular degeneration (AMD) that involves abnormal blood vessel growth, in one or both eyes
• The vision in your study eye (the eye being treated) is quite poor but not completely lost — within a specific range of reduced vision (confirm with trial site for exact details)
• You meet at least one of the following eye conditions in your study eye: the central part of your retina (fovea) is affected by a tear or scarring in the back layer of the eye; or a specific area of damage has spread to the centre of your vision; or your eye has thinning of the tissue behind the retina with fluid that has not responded to standard treatment, but without certain signs of high-risk damage; or you have a specific type of fluid build-up and cell damage in the retina, again without certain high-risk signs (confirm details with trial site)
• Your eye condition has not improved — or your vision has gotten worse — after two recent consecutive anti-VEGF injections (a common treatment for AMD) given 4 to 8 weeks apart

Who may not be able to join:

• You have a specific type of raised tissue change (pigment epithelial detachment of a certain thickness) at the centre of your study eye (confirm with trial site)
• You have hard deposits (hard exudates) in the layers of your study eye's retina
• You currently have an eye infection in your study eye
• You have a history of other retinal diseases, detached retina, a hole in the central part of your retina, inflammation inside the eye, or other eye diseases (other than AMD) in your study eye
• You have damage to the optic nerve in your study eye
• You have glaucoma in your study eye that is getting worse or is not well controlled
• You have severe short-sightedness in your study eye, based on the size of your eye or your lens prescription
• You have had surgery inside your study eye (cataract surgery may be acceptable if it went well, there were no complications, and it was more than 3 months ago — confirm with trial site)
• The vision in your other (non-study) eye is very poor, below a certain level (confirm with trial site)
• You are currently receiving or planning to receive anti-VEGF injections in your other (non-study) eye during the trial
• You have abnormal results from screening tests that the trial team believes would affect your safe participation
• You have tested positive for certain infections including Hepatitis B, Hepatitis C, HIV, HTLV-1, or syphilis
• You have a known allergy to human serum albumin, antibiotics, or trypsin
• You have serious conditions affecting your blood, heart, liver, or kidneys
• You have been diagnosed with cancer within the last 5 years, or are currently receiving cancer treatment
• You are pregnant, breastfeeding, or plan to become pregnant during the trial
• You are taking blood-thinning or antiplatelet medications that you cannot stop before the trial
• You have a history of drug addiction or alcoholism

Important: Always verify eligibility with the trial site directly before applying.