Phase 3 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with kidney cancer (specifically clear cell renal cell carcinoma) that cannot be removed by surgery and has either spread to other parts of the body or is advanced locally.
• People whose overall health and ability to carry out daily activities meets a certain minimum level, as measured by a standard scoring tool called the Karnofsky Performance Status (a score of 80% or higher).
• People who have at least one area of cancer that can be clearly measured on a CT or MRI scan, located outside any area that has previously been treated with radiation.
• People whose blood test results show that major organs such as the liver, kidneys, and bone marrow are functioning adequately (tested within one week before joining the trial).
• Women who could potentially become pregnant must have a negative blood pregnancy test before joining.

Who may not be able to join:

• People who have previously been treated with a type of drug called a HIF-2α inhibitor, or with a drug called cabozantinib.
• People who have had another type of cancer that has been active within the past year, unless it was a localised cancer that appears to have been fully treated and cured.
• People who are still experiencing significant side effects from previous cancer treatments, or who have had severe side effects (Grade 3 or higher on a standard medical scale) from any prior cancer therapy.
• People with high blood pressure that remains poorly controlled (above 150/90 mmHg) even while receiving appropriate blood pressure medication.
• People with a history of cancer spreading to the membranes surrounding the brain or spinal cord, or who have experienced compression of the spinal cord.

Important: Always verify eligibility with the trial site directly before applying.