Rheumatoid Arthritis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 75 years old (male or female)
- You have been diagnosed with rheumatoid arthritis (RA) that started when you were 18 or older, and a specific blood test for RA (RF, CCP, or ACPA) has come back positive
- Your RA is moderately to severely active, with at least 4 tender and 4 swollen joints (out of 28 checked)
- Your RA has not improved enough after trying at least 2 biologic or targeted treatments (such as JAK inhibitors) for 3 months, or you were unable to tolerate them
- You have been on a stable, unchanged dose of at least one RA medication for more than 8 weeks before the study starts, and you are willing to stay on it throughout the trial
- If you are a woman who could become pregnant, you must not currently be pregnant or trying to become pregnant, and you agree to use reliable contraception throughout the trial
- You are eligible for Medicare
- You are willing and able to sign a consent form agreeing to take part
Who may not be able to join:
- You are unwilling or unable to sign a written consent form
- You have a major psychiatric condition that is not well-controlled (note: stable, well-managed depression or anxiety may still be acceptable — confirm with trial site)
- You have a medical condition that could interfere with the study or make results harder to interpret, as decided by the study doctor
- You have severe nerve damage affecting automatic body functions (such as poorly controlled type 2 diabetes) (confirm with trial site)
- You have previously had certain surgeries, including removal of the vagus nerve (vagotomy), removal of the spleen, or weight-loss (bariatric) surgery
- You have a history of a hiatus hernia (where part of the stomach pushes up into the chest)
- You already have an implanted medical device (such as a pacemaker, spinal cord stimulator, or drug pump), or you are likely to need one within 6 months of starting the study
- You regularly need MRI scans for any ongoing medical condition
- The study doctor does not consider you a suitable candidate for any other reason
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: A/Prof Shereen Oon, St Vincent's Hospital Melbourne
Phone: +61392311203
Australian sites
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
3 site(s) in Australia. Confirm current status and contact details directly with the trial site.
Primary endpoints
Safety of aVNS in individuals with drug refractory moderate-severe adult-onset RA.; Safety of aVNS in individuals with drug refractory moderate-severe adult-onset RA.; Safety of aVNS in individuals with drug refractory moderate-severe adult-onset RA.
Can't join this trial?
Data last synced from ClinicalTrials.gov: 23 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.