Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are at least 18 years old.
• People who have a good general level of physical functioning, rated 0 or 1 on a standard oncology scale (meaning fully active or able to carry out light activity).
• People who are able to understand and agree to take part by giving informed consent.
• People who have been diagnosed with stage III or IV ovarian cancer, fallopian tube cancer, or primary peritoneal cancer — confirmed by tissue or cell testing — where upfront surgery to remove the tumour is not suitable.
• People who are planned to receive chemotherapy before surgery (called neoadjuvant chemotherapy), using a platinum-based drug, with or without bevacizumab or a similar medicine, including those already planned for surgery after that chemotherapy.
• People who have a measurable CA125 blood marker level at the start of the trial — specifically, at least twice the upper limit of the normal range.
• People who have had a CT scan or PET-CT scan of at least the abdomen and pelvis before joining (an MRI scan is also acceptable), and who are able to use the same type of scan later to assess surgical planning.
• People who agree to undergo surgery to remove as much tumour as possible after chemotherapy, even if the timing may differ from standard practice.
• People who agree to receive further chemotherapy after surgery if the treating doctor considers it medically appropriate, with a total of at least four chemotherapy cycles overall.

Who may not be able to join:

• People whose cancer is classified as borderline (low malignant potential), or is a non-epithelial type such as germ cell tumour or sex cord tumour, or has spread from a cancer that started in another organ (such as a Krukenberg tumour).
• People whose cancer is considered suitable for upfront surgery to remove the tumour directly.
• People who are not considered suitable for surgery due to other medical conditions, or who do not wish to have surgery.
• People who have already begun chemotherapy before joining the trial at another centre — except those who have had only one cycle within the past 21 days and whose baseline CA125 result is available.
• People who are pregnant.

Important: Always verify eligibility with the trial site directly before applying.