Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 years or older
• People whose general health and activity level has been assessed by a doctor as being largely normal or only mildly affected by their illness (confirmed within 28 days before joining)
• People who are able to give signed consent to participate
• People with stage III or IV ovarian cancer, fallopian tube cancer, or primary peritoneal cancer that has been confirmed by a tissue or cell sample, and where upfront surgery is not considered appropriate
• People who have had a CT scan of the chest, abdomen, and pelvis as a starting point before joining
• People who are planned to receive a standard chemotherapy combination (carboplatin and paclitaxel, given every 3 weeks) before surgery — people who have already received one cycle of this chemotherapy may still be considered, provided certain blood test timing requirements can be met (confirm with trial site)
• People who have a measurably elevated CA125 blood marker at the start (at least twice the upper limit of the normal range)
• People who agree to consider surgery to remove the tumour (called interval debulking surgery) if the cancer becomes operable after chemotherapy
• People whose blood counts and liver and kidney function are at levels considered safe enough for chemotherapy
• People who agree to receive further chemotherapy after surgery, with a total of at least four chemotherapy cycles and no more than nine
• People of childbearing potential who agree to use highly effective contraception throughout the study and for at least 30 days after treatment ends
• People who have had genetic testing for BRCA gene changes (either inherited or in the tumour) or for a related DNA repair deficiency (called HRD)

Who may not be able to join:

• People whose cancer is classified as borderline, or is a type other than epithelial ovarian cancer (such as germ cell or sex cord tumours), or is a cancer that has spread from another part of the body
• People whose ovarian cancer is of mucinous or neuroendocrine cell type
• People who have had another cancer diagnosed within the past five years
• People whose cancer is considered suitable for upfront surgery (primary debulking surgery)
• People whose surgery is not possible only because of cancer involvement in specific nearby areas (the parametrium and/or vagina alone)
• People who are not considered suitable for surgery because of other health conditions, or who have declined surgery
• People who have already begun chemotherapy at a centre outside the study, unless they have had only one cycle within the past 7 days and a qualifying CA125 blood test result taken within 3 days of starting that chemotherapy is available (confirm with trial site)
• People who are already taking part in another clinical trial involving a treatment intervention
• People who are pregnant or breastfeeding
• People who have medical reasons why they cannot receive platinum-based chemotherapy
• People with active tuberculosis, a known positive HIV test result, or a diagnosis of AIDS

Important: Always verify eligibility with the trial site directly before applying.