Stroke Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 18 and 85 years of age at the time of enrolment
• People who have leg difficulties caused by a stroke on one side of the body, where the stroke happened at least 6 months before screening
• People with moderate to severe walking difficulties, meaning the fastest walking speed possible is no more than 0.8 metres per second (roughly half of a typical walking speed)
• People who are able to stand up without help from another person or a device
• People who have a noticeable unevenness or imbalance in the way they walk, as observed by a clinician
• People who show an abnormal muscle activation pattern between two specific leg muscles — the adductor magnus and rectus femoris — as measured during assessment (confirm with trial site)

Who may not be able to join:

• People with thinking or attention difficulties that affect performance on a specific attention test (digit-span test), or who are unable to follow the instructions of a particular memory task used in the trial
• People with vision problems (such as loss of half the visual field) that would prevent them from seeing a screen well enough to participate in the game-based activities
• People with severe numbness, loss of sensation, or significant inattention affecting the stroke-affected leg, or a visual attention condition, at a level that would interfere with the game-based tasks
• People who have participated in another study involving the affected leg, or any medication-based study, within 6 weeks of enrolment
• People who are unable to understand or follow spoken instructions in English due to speech or language difficulties, or any other reason that would make training impossible
• People with widespread or multiple areas of stroke-related brain injury
• People experiencing significant leg pain or other pain that would prevent participation in 60-minute daily sessions
• People who have received spasticity treatment — whether medication or Botox injections — in the affected leg within the past 3 months
• People with severe bone thinning (osteoporosis) that has led to hip or other fractures
• People with a history of multiple falls in the past year, those who use a walker for balance, or those who fall while standing during the first lab session
• People with joint stiffness or tightening in the leg that limits its range of movement
• People who are currently pregnant
• For the brain stimulation (TMS) part of the study only: people with a history of epilepsy in adulthood requiring seizure medication; current or recent significant alcohol, benzodiazepine, or barbiturate misuse or recent withdrawal from these substances; recent cocaine or amphetamine use; skull fractures or gaps in the skull; a concussion within the last 6 months; unexplained recurring headaches; or certain implanted medical devices including a vagus nerve stimulator, cochlear implant, deep brain stimulator, brain or neck artery stents, or a heart pacemaker or defibrillator

Important: Always verify eligibility with the trial site directly before applying.