Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 80 years, of any gender
• People who have been clinically diagnosed with an ischemic stroke (a stroke caused by a blockage), following recognised Chinese stroke diagnosis guidelines
• People where treatment can begin within 6 hours of when symptoms first started, where symptoms have lasted at least 30 minutes and have not significantly improved before treatment
• People who show at least some measurable stroke symptoms at the start of the trial, as assessed by a standard medical scale (NIHSS score of 1 or more)
• People, or their legal guardians, who are willing to sign a consent form agreeing to take part

Who may not be able to join:

• People whose brain scan (CT or MRI) shows a large area of damage covering more than one-third of a specific brain artery's territory (the middle cerebral artery)
• People where the exact time their stroke symptoms began is not known
• People who already had some level of disability before the stroke, based on a standard disability scale (pre-stroke mRS score of 2 or higher)
• People with a significantly reduced level of consciousness, as measured by a specific part of the stroke assessment scale (NIHSS item 1A score of 2 or more)
• People who have any bleeding inside the skull, such as a brain bleed, bleeding into fluid-filled spaces, bleeding around the brain, or bleeding between the skull and brain
• People with a previous history of bleeding inside the skull
• People with a tendency to bleed easily, including those with a low platelet count (below 100 × 10⁹/L) or other bleeding-related conditions
• People who have received heparin (a blood-thinning medication) within the past 24 hours
• People taking oral blood-thinning medications (such as warfarin) whose blood test results show their blood is thinning more than a certain level (INR above 1.7 or PT above 15 seconds)
• People who have had, or are planned to have, a procedure to treat the stroke from inside the blood vessels (endovascular therapy)
• People who have had a serious head injury or stroke within the past 3 months
• People with a tumour inside the skull or a large brain aneurysm (a bulge in a blood vessel in the brain)
• People who have had surgery inside the skull or on the spine within the past 3 months
• People who have had a major surgical procedure within the past 2 weeks
• People with serious liver disease, such as liver failure, cirrhosis, high blood pressure in the liver's blood vessels, or active hepatitis
• People who have had bleeding in the stomach, intestines, or urinary tract within the past 3 weeks
• People who currently have active bleeding inside the body
• People found to have a tear in the main large blood vessel from the heart (aortic dissection)
• People who have had a needle inserted into an artery in a location that is difficult to apply pressure to, within the past week
• People who are not expected to survive beyond one year due to other serious health conditions
• People with very high blood pressure that cannot be controlled even with medication — specifically, a top reading at or above 180 mmHg or a bottom reading at or above 100 mmHg, confirmed across three separate measurements taken 10 minutes apart
• People whose blood sugar level is very low (below 2.8 mmol/L) or very high (above 22.2 mmol/L)
• People who are unable or unwilling to participate due to a seizure-related weakness, or due to other neurological or psychiatric conditions
• People with a known allergy to urokinase (the medication being studied)
• People with a bacterial infection of the heart lining, inflammation around the heart, or acute inflammation of the pancreas
• People who have taken part in another clinical trial within the 30 days before being assessed for this trial
• People who are pregnant, breastfeeding, or not willing to use effective contraception during the trial
• People who the trial investigator considers unsuitable for any other reason that may affect their safety or ability to follow the trial requirements

Important: Always verify eligibility with the trial site directly before applying.