Phase 3 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a type of breast cancer that is hormone receptor positive (HR+) and HER2 negative, and the cancer has either spread to other parts of the body or is locally advanced and cannot be completely removed by surgery
• Your cancer has been tested and confirmed through a biopsy (a tissue sample taken during or after your most recent treatment) to have certain specific characteristics related to hormone receptors, HER2, and a protein called HER3
• Your cancer got worse or came back while you were being treated with a specific combination of drugs called a CDK4/6 inhibitor plus hormone therapy — either as your first treatment for advanced cancer, or during or within 2 years of finishing a similar combination given after surgery
• Your cancer can be measured on scans using standard medical guidelines (confirm with trial site)
• If you have HIV, it must be well controlled with medication
• You are in good general health, able to carry out daily activities with little or no limitation, as assessed by your doctor within 7 days before joining the trial

Who may not be able to join:

• Your breast cancer could potentially be cured with treatment
• Your doctor believes you could still benefit from further hormone-based treatments for advanced disease
• You carry a specific inherited gene change (BRCA mutation) where a type of drug called a PARP inhibitor could be used to treat you
• Your cancer is causing or is about to cause serious, life-threatening problems with your internal organs
• Your blood oxygen level at rest is below 92%, or you need oxygen support at any time
• You have serious, uncontrolled heart or blood vessel disease
• You have moderate or severe nerve damage causing numbness, tingling, or pain (Grade 2 or higher peripheral neuropathy)
• You have a significant eye or cornea condition
• You have previously received chemotherapy for advanced or metastatic breast cancer
• You have previously been treated with a specific type of drug that targets the HER3 protein, or a drug combining an antibody with a chemotherapy agent that works in a similar way to the drug being studied in this trial
• You have received cancer treatment too recently before joining the trial (within 4 weeks or 5 half-lives, whichever is shorter — though patients previously on hormone therapy plus a CDK4/6 inhibitor may qualify if at least 2 weeks have passed)
• You have had radiotherapy to areas other than the brain within 14 days before starting the trial, or needed steroids because of radiation side effects in that time
• You have a condition that weakens your immune system, or you regularly take steroid medications
• You have another cancer that is active or has required treatment within the past 3 years
• You have a history of lung inflammation (pneumonitis or interstitial lung disease) that needed steroids, or you currently have or may have this condition
• You have had a severe allergic reaction to the study drug or any of its ingredients
• You have had a severe allergic reaction to all of the alternative standard treatments used in this trial (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.