Phase 3 Cervical Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been newly diagnosed with cervical cancer that has been confirmed by a tissue test (pathology), specifically one of these types: squamous cell carcinoma, adenocarcinoma, or adenosquamous cell carcinoma
• People whose cervical cancer is locally advanced, meaning it has grown into nearby tissues and/or nearby lymph nodes, but has not spread to distant parts of the body (this covers certain specific stages, so the trial site can confirm which stages apply)
• People whose cancer has not spread to lymph nodes in the upper part of the abdomen (above a specific spinal level known as T12/L1)
• People who have not previously had their entire uterus removed (though removal of only part of the uterus for a reason unrelated to cervical cancer may still be acceptable — confirm with trial site)
• People for whom a hysterectomy is not planned as part of their cervical cancer treatment
• People who have not previously received surgery, radiation, or drug-based treatment for cervical cancer
• People who have never received immunotherapy treatment
• People who have never had radiation therapy to the pelvic area for any condition
• People aged 18 or older
• People who are well enough to carry out basic daily activities, based on a standard medical fitness scale (ECOG performance status of 2 or lower — confirm with trial site)
• People who are not currently pregnant and not breastfeeding
• People whose blood counts meet minimum levels: white blood cells, platelets, and red blood cells are all within required ranges (confirm specific values with trial site)
• People whose kidneys are functioning well enough, based on a calculation of kidney filtration rate
• People whose liver function blood test results are within acceptable ranges
• People with a heart condition, if present, must be assessed as having heart function at a certain level or better on a standard heart health scale (confirm with trial site)
• People who do not have an active infection that requires intravenous antibiotics
• People who have not received a live vaccine (such as measles, mumps, rubella, chickenpox, yellow fever, rabies, BCG, or live nasal flu vaccine) within the 30 days before joining the trial — injected seasonal flu vaccines are generally acceptable
• People who do not have an immune system disorder and are not taking immune-suppressing medications or steroids above a certain dose within 7 days before joining
• People who do not have an active autoimmune disease that has needed systemic medical treatment in the past 2 years — hormone or other replacement therapies (such as thyroid or insulin) are generally acceptable
• People who have no history of lung inflammation (pneumonitis) that required steroid treatment, and no current lung inflammation
• People who have no known allergic reaction to the study drugs or to similar types of medications

Who may not be able to join:

• People whose cervical cancer has spread to distant parts of the body
• People whose cancer has spread to lymph nodes high in the abdomen (above the T12/L1 spinal level)
• People who have already had their entire uterus removed
• People for whom a hysterectomy is planned as part of their cervical cancer treatment
• People who have previously received any treatment for cervical cancer (surgery, radiation, or systemic drug therapy)
• People who have previously received immunotherapy
• People who have previously had radiation to the pelvic area for any reason
• People under 18 years of age
• People whose general health and physical function fall below a certain level on the standard medical fitness scale
• People who are currently pregnant or breastfeeding
• People whose blood counts, kidney function, or liver function do not meet the required minimum levels
• People with a heart condition assessed as below a certain level of heart function on the standard heart health scale
• People with an active infection requiring intravenous antibiotics
• People who have received a live vaccine within 30 days before joining the trial
• People currently taking immune-suppressing medications or steroids above a certain dose
• People with an active autoimmune disease that has required systemic treatment in the past 2 years
• People with a history of lung inflammation that required steroids, or who currently have lung inflammation
• People with a known allergy to the study drugs or closely related compounds

Important: Always verify eligibility with the trial site directly before applying.