Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older.
• You have been diagnosed with a solid tumor (confirmed by lab testing) that has stopped responding to, or has come back after, at least two previous treatments.
• Your cancer is one of the following types: soft tissue sarcoma, triple-negative breast cancer, cervical cancer, non-small cell lung cancer, ovarian cancer, or pancreatic ductal adenocarcinoma with a specific KRAS gene mutation.
• Your cancer can be measured using standard imaging scans.
• You are reasonably active and able to care for yourself, with only mild limitations in daily activity (confirm with trial site).
• Doctors expect you to live for at least 12 weeks.
• If you are HIV-positive, you have been on stable HIV treatment for at least four weeks and your HIV levels in the blood are very low.
• Your heart is pumping blood efficiently enough (confirmed by a heart scan).
• Your blood counts, liver, and kidney functions are all within acceptable ranges (confirm with trial site for specific numbers).
• If you have a specific liver condition called Gilbert's disease, your bilirubin level must be below a certain level (confirm with trial site).
• You have waited long enough since your last cancer treatment before joining: at least 3 weeks after chemotherapy, and at least 4 weeks after radiation, immunotherapy, other targeted therapies, or surgery.
• Any side effects from your previous treatments have mostly gone away.
• If you are a woman who could become pregnant, you have had a negative pregnancy test within 7 days before starting treatment and agree to use effective birth control during the study and for 6 months after your last dose.
• If you are a man who could father a child, you agree to use effective birth control during the study and for 6 months after your last dose.

Who may not be able to join:

• Your cancer has a known gene mutation for which effective targeted treatments exist, but you have not yet tried those treatments (if you have already tried them and they stopped working, or they are not suitable for you, you may still be eligible — confirm with trial site).
• You have had unstable chest pain, a heart procedure (such as angioplasty or stenting), or a heart attack within the last 6 months.
• You have cancer that has spread to the brain or spinal cord and has not been treated.
• You have previously received doxorubicin or a similar type of chemotherapy drug (called an anthracycline).
• You have previously had radiation treatment to the chest area around your heart.
• You have a known allergy to albumin (a protein found in blood).
• You are HIV-positive with a very low immune cell count, or you have had a serious HIV-related infection in the past 12 months.
• You are pregnant or breastfeeding.
• You have taken part in another experimental drug or device trial within the last 4 weeks.
• You have diabetes that is not well controlled.
• You are currently taking certain medications that strongly affect how drugs are processed in your body (confirm with trial site which specific medications apply).

Important: Always verify eligibility with the trial site directly before applying.