Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Doctors expect you to live for at least 3 more months.
• You have been diagnosed with ovarian cancer (including fallopian tube or peritoneal cancer) that has come back or stopped responding to standard treatments, confirmed by a tissue or cell sample test.
• You have already received at least one round of platinum-based chemotherapy and your cancer has continued to grow, or your cancer does not respond well to platinum-based treatment, and there are no other standard treatments available that could cure it.
• Your tumor tissue sample shows positive levels of two specific proteins (CD146 and GPC3) when tested in a lab — both must be present.
• You have at least one area of cancer that can be clearly measured on a scan.
• You are 18 years of age or older.
• You are generally well enough to carry out daily activities, or only limited when it comes to strenuous physical effort (confirm with trial site).
• Your heart, liver, kidneys, and bone marrow are working well enough to meet the trial's health requirements, including acceptable blood counts and organ function levels.
• You are able to understand and sign a consent form and are willing to follow all trial procedures and attend follow-up visits.
• If you are able to become pregnant, you must have a negative pregnancy test before joining and agree to use reliable contraception during the study and for a set period afterward.

Who may not be able to join:

• You have previously received a CAR-T cell therapy or any other gene-engineered T-cell treatment targeting the same proteins (CD146 or GPC3).
• You currently have active cancer spread to the brain or the lining around the brain and spinal cord (confirm with trial site if you have a history of treated brain metastases).
• You have a serious, uncontrolled illness such as an active serious infection, significant heart failure, unstable heart condition, or a mental health or personal situation that would make it hard to follow the study requirements.
• You have an active hepatitis B or C infection with detectable virus in your blood, or HIV with a viral level that is not controlled.
• You need to take long-term medicines that suppress your immune system (for example, for an autoimmune disease or after an organ transplant), except for very low-dose steroids.
• You are currently pregnant or breastfeeding, or you are able to become pregnant but are unwilling or unable to use adequate contraception.
• You currently have another active cancer that requires treatment (some exceptions may apply — confirm with trial site).
• You have a known severe allergic reaction to any part of the CAR-T cell treatment or to the chemotherapy drugs used to prepare your body before the treatment (cyclophosphamide or fludarabine).
• Your doctor or the trial team feels that any other health condition makes you unsuitable for this study.

Important: Always verify eligibility with the trial site directly before applying.