COPD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are aged between 35 and 80 years old.
• People who have chronic bronchitis, meaning they have had a mucus-producing cough for at least three months a year, for two years in a row, and other causes of that cough have been ruled out.
• People whose symptom burden score on a standard lung disease questionnaire (called the CAT) is 10 or higher.
• People whose quality-of-life score on another standard lung questionnaire (called the SGRQ) is 25 or higher.
• People whose answers to the first two CAT questions add up to 7 or more points, or add up to 6 points when their total CAT score is above 20 (confirm with trial site).
• People whose breathing test results show a specific pattern of airflow limitation (FEV1/FVC ratio below 0.70).
• People whose lung function, measured after using a bronchodilator (airway-opening medication), is at least 30% of what would normally be expected for someone of their age and size.
• People who have been using at least one long-acting inhaler medication (a type that keeps the airways open) for at least 8 weeks before joining the trial — with or without an inhaled steroid — unless they have tried this type of medication in the past year without meaningful benefit or had a bad reaction to it.
• People who, in the lead doctor's opinion, are well enough to undergo two bronchoscopy procedures under general anaesthetic and are able to attend all scheduled follow-up appointments.
• People who have signed an informed consent form, or whose legal representative has done so on their behalf.

Who may not be able to join:

• People who have an active, unresolved lung infection, such as pneumonia, tuberculosis, or a fungal infection.
• People who need more than 10 mg of oral steroid tablets daily to manage another health condition.
• People who have an implanted electronic device (such as a pacemaker or defibrillator) that cannot be switched off during the procedure.
• People who have had certain serious heart rhythm problems within the past two years, or a resting heart rate below 45 beats per minute — unless that condition has been treated and their heart rhythm is normal during the screening period.
• People who have lung cancer.
• People who have a spot or cavity on their lung that the lead doctor believes may need further treatment during the course of the study.
• People who have previously had lung surgery, including lung transplant, lung volume reduction surgery, removal of part of a lung, a lung implant or prosthesis, metal airway stents, valves, coils, or removal of air-filled sacs in the lungs.
• People whose CT scan shows that 50% or more of their lung tissue is affected by emphysema (air trapping and lung damage).
• People who have been diagnosed with asthma, based on internationally recognised criteria.
• People who have bronchiectasis (widened and damaged airways) that is causing or significantly contributing to their cough and phlegm symptoms.
• People who have smoked anything — including tobacco, marijuana, e-cigarettes, or vaping products — within the past two months.
• People who are unable to walk more than 225 metres within 6 minutes.
• People who have a serious medical condition that the lead doctor believes could put them at risk or make it harder to assess their response to treatment — for example, severe heart failure, a heart attack in the past year, kidney failure, liver disease, a stroke in the past 6 months, poorly controlled diabetes, uncontrolled high blood pressure, autoimmune disease requiring immunosuppressant medications, or a condition requiring chemotherapy.
• People who have uncontrolled acid reflux (GERD).
• People who have known severe high blood pressure in the lungs (pulmonary hypertension).
• People who have a known allergy or sensitivity to medications typically used during a bronchoscopy procedure, such as lidocaine, atropine, or benzodiazepines.
• People who are currently pregnant, breastfeeding, or planning to become pregnant during the study period.
• People who are already taking part in another clinical trial involving an investigational (experimental) treatment.
• People who are taking blood-thinning medications for a heart condition and, in the lead doctor's opinion, cannot safely stop those medications during the bronchoscopy procedure.
• People who are known to have antibiotic-resistant bacteria or significant fungal organisms present in their airways.

Important: Always verify eligibility with the trial site directly before applying.