Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 80 years, of any gender
• People who are reasonably active and able to care for themselves, or who need only limited help with daily activities (this is measured using a standard scale called ECOG, levels 0–2)
• People with a life expectancy of more than 3 months
• People who have at least one measurable tumour site that can be tracked over time using standard imaging measurements
• People with solid tumours that have spread to other parts of the body (of any tumour type), where no standard treatment options remain, and whose cancer got worse after previously receiving immunotherapy, immunotherapy combined with chemotherapy, or immunotherapy combined with anti-blood-vessel-targeting treatment
• People who are not considered suitable candidates for surgery
• People who have brain metastases (cancer that has spread to the brain) that have been assessed as stable following treatment, confirmed by repeated CT and/or MRI scans
• People who have complete medical and pathology records available
• People who are not facing personal, family, social, or location-related circumstances that would make it difficult to follow the trial requirements
• People who are able to understand and voluntarily sign an informed consent form

Who may not be able to join:

• People for whom radiation therapy or immunotherapy is medically not suitable
• People who have previously experienced serious immune-related side effects that were not tolerable, such as immune-related heart inflammation or lung inflammation
• People whose cancer was assessed as having rapidly progressed (grown faster than expected) during prior immunotherapy — sometimes called hyperprogressive disease
• People who have received radiation therapy to the pelvis or abdomen within the 6 months before joining the trial
• People whose side effects from previous treatments have not yet recovered to a mild level (based on a standard grading scale), except for side effects already confirmed to be low-risk, such as tiredness or hair loss
• People with active infections (bacterial, viral, or fungal) that are not controlled despite treatment
• People with significant liver or kidney problems, shown by blood test results more than 3 times above the normal upper limit
• People with active hepatitis B, hepatitis C, HIV, or syphilis
• People with brain disorders, active symptoms from cancer spread to the brain or surrounding membranes, or significant problems with thinking or memory
• People who have a known allergy or sensitivity to any of the drugs used in this trial
• People with a current problem with drug and/or alcohol misuse
• People who are pregnant or breastfeeding
• People who are currently taking part in another treatment-based clinical trial
• People with poorly controlled fluid build-up around the lungs, heart, or abdomen that requires drainage more than once every 14 days
• People who have had major surgery within the 30 days before joining the trial
• People who have taken antibiotics, antifungal, antiviral, antiparasitic medications, or probiotics within the 4 weeks before joining the trial

Important: Always verify eligibility with the trial site directly before applying.