Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 50 and 80 years old, of any gender
• People who have been diagnosed with Alzheimer's disease (AD) using a recognised set of medical guidelines called the NIA-AA criteria
• People whose Alzheimer's disease is at a moderate-to-severe stage, based on a standard rating scale used by doctors (CDR-GS score of 1 or higher)
• People who score between 10 and 20 on a standard memory and thinking test called the MMSE
• People who have had Alzheimer's disease for more than 6 months
• People who are either not taking any Alzheimer's medication, or who have been on a stable dose of an approved Alzheimer's medication for at least 3 months before the study starts
• People who have an identified caregiver — someone who spends at least 8 hours per week with them, is able to support them throughout the whole study, and can attend all follow-up visits with them
• People (or their relative, along with their caregiver) who have signed a consent form agreeing to take part

Who may not be able to join:

• People who have another neurological condition besides Alzheimer's disease that could affect memory or thinking, such as stroke, Parkinson's disease, epilepsy, brain tumours, traumatic brain injury, brain infections, or metabolic brain conditions
• People whose dementia is caused by something other than Alzheimer's disease, such as vascular dementia, a hereditary blood vessel condition, vitamin deficiency, or another cause
• People who have previously been found to have a severe narrowing (70% or more) of certain major blood vessels in or leading to the brain
• People who have a primary psychiatric condition such as schizophrenia, schizoaffective disorder, major depression, or bipolar disorder (not including psychiatric symptoms that are caused by Alzheimer's disease itself)
• People who have severe difficulties with movement, speech, vision, hearing, or consciousness, or any condition the trial doctor believes would prevent them from completing thinking and memory assessments
• People with a history of drug or alcohol abuse or dependence
• People with a history of cancer (malignant tumours), or who have previously had radiotherapy or surgery involving the head or neck
• People who have had major surgery or a serious head or body injury within the past 30 days
• People who have another life-threatening condition and are expected to survive less than 2 years
• People who are unable to have a head MRI scan — for example, due to having a pacemaker, defibrillator, or certain metal implants in the body
• People who have serious heart, lung, liver, kidney, or other organ problems that would make it unsafe for them to undergo anaesthesia or the procedure being studied
• People with serious bleeding problems, including a low platelet count, recent heparin treatment with certain blood test results above set thresholds, or warfarin use with a blood clotting result above the trial's cut-off level (confirm with trial site)
• People who need to take blood-thinning medications long-term and for whom stopping them before surgery would not be possible or would carry significant risk
• People with uncontrolled high blood pressure (above 160/95 mmHg)
• People who have HIV, syphilis (Treponema pallidum infection), or any other uncontrolled infectious disease
• People who have taken part in another clinical trial or used an investigational drug or device within 30 days before signing the consent form, or who are currently in another interventional clinical study
• People who are pregnant, breastfeeding, capable of becoming pregnant, or planning to become pregnant during the study period
• Immediate family members of the trial investigators or staff (such as spouses, parents, children, or siblings), employees of the research institution or related organisations, or anyone else with a potential conflict of interest related to the study

Important: Always verify eligibility with the trial site directly before applying.