Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 75 years old (inclusive)
• People who are able to understand and are willing to sign a written consent form
• People whose general physical functioning falls within a certain range, as measured by a standard oncology scale called the ECOG scale (scores 0 to 3) (confirm with trial site)
• People who researchers estimate have a life expectancy of at least 3 months
• People who have been diagnosed with a type of brain and spinal cord lymphoma called primary central nervous system lymphoma (PCNSL) of B-cell origin, confirmed by laboratory testing of tissue or fluid samples
• People whose lymphoma can be measured on an MRI scan, with at least one area measuring 1.0 cm or more
• People whose PCNSL has come back or stopped responding to treatment, and who have already received at least one round of treatment that included a drug called high-dose methotrexate
• People whose side effects from previous cancer treatments have mostly resolved to a mild or normal level (with the exception of hair loss)
• People whose bone marrow, liver, kidneys, and blood clotting function meet specific levels set by the trial (confirmed through blood tests, without blood transfusions or certain medications in the 14 days before screening) (confirm with trial site for exact values)
• People who are willing to use effective contraception during the trial and for 6 months after the last dose — this applies to both women who could become pregnant and men who are sexually active
• People who are able to undergo multiple MRI or CT scans and lumbar puncture (spinal fluid) procedures during the trial
• People who are able to swallow tablets or capsules without difficulty
• People who are willing to follow the trial's schedule, including visits, medications, and required tests

Who may not be able to join:

• People who have received chemotherapy, radiation, immunotherapy, antibody therapy, herbal anti-cancer treatments, or certain targeted therapies within a recent period before the trial starts (ranging from 2 to 10 weeks depending on the type of treatment) (confirm with trial site)
• People who have participated in another clinical trial using an investigational treatment within 4 weeks before the trial start date
• People who have used high-dose steroid medications for more than 5 days within the 14 days before starting the trial, or who need more than a certain daily amount of steroids to manage their condition (confirm with trial site)
• People who currently have another active cancer that requires treatment
• People who have received certain specific treatments — including anti-PD-1, anti-PD-L1, anti-PD-L2, selenidazole, or teniposide — within the 6 months before starting the trial
• People with serious or uncontrolled heart conditions, including severe heart failure, recent heart attack, unstable chest pain, certain abnormal heart rhythms, reduced heart pumping function, certain types of heart muscle disease, significant irregular heart electrical activity, or poorly controlled high blood pressure
• People with an active, uncontrolled infection or an infection currently being treated with intravenous antibiotics
• People with active hepatitis B, active hepatitis C, syphilis, or HIV infection (note: people with inactive hepatitis B who are on effective suppressive treatment, or people who have been cured of hepatitis C, may still be considered eligible — confirm with trial site)
• People with significant digestive system problems that could affect how a tablet is absorbed, such as active gut inflammation, ongoing diarrhoea, bowel blockage, or those who have had their entire stomach removed or had gastric banding surgery
• People who have previously had an allogeneic stem cell transplant (a transplant using donated stem cells), or who are planning to have one
• People who are currently pregnant or breastfeeding
• People who are allergic to the trial drug or any of its ingredients
• People with active mental illness or current problems with alcohol, drug, or substance misuse
• People with any other serious medical condition that researchers believe could put the person at risk or affect their ability to follow the trial procedures
• People who researchers determine are otherwise not suitable for the trial for any other reason

Important: Always verify eligibility with the trial site directly before applying.