Phase 3 Breast Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are female and between 18 and 75 years old
• People who are well enough to carry out most daily activities (assessed using a standard medical scale called the Karnofsky Performance Status, with a score of 60 or above)
• People who have been confirmed through laboratory testing to have invasive breast cancer (a specific type called adenocarcinoma)
• People who have had a full mastectomy (removal of the whole breast, with or without preservation of the nipple and surrounding skin area), along with removal or sampling of underarm lymph nodes, and placement of a breast implant or tissue expander — and where the surgery removed all visible cancer with clear margins
• People whose cancer was at a certain stage at the time of surgery: either stage pT3 or with cancer spread to multiple lymph nodes (N2–3), or earlier-stage tumour with limited lymph node involvement (pT1–2N1) (confirm with trial site if unsure which category applies)
• People who have no cancer that has spread to distant parts of the body
• People who have completed their full course of standard chemotherapy given either before or after surgery
• People who are entering the trial within 8 weeks of finishing chemotherapy, or within 12 weeks of surgery if no chemotherapy was given
• People who have read and signed a consent form agreeing to take part in the trial

Who may not be able to join:

• People who have previously had radiation therapy to the chest wall or nearby lymph node areas
• People who are currently pregnant or breastfeeding
• People whose cancer was classified as T4 stage (confirm with trial site)
• People who have had breast reconstruction using their own body tissue (autologous reconstruction) in the breast that would be treated with radiation
• People who have any cancer recurrence — local, regional, or distant — detected before radiation treatment begins
• People who have serious implant-related complications (graded 3 or above on a standard medical scale) that have not resolved before radiation treatment starts
• People who have cancer in both breasts and would require radiation to both sides
• People who have or have had another cancer diagnosed within the last 5 years — except for certain low-risk cancers such as non-melanoma skin cancer, certain thyroid cancers, or a very early form of cervical cancer
• People who have an active connective tissue disease such as lupus or scleroderma
• People who have uncontrolled serious health conditions, including active heart or cardiovascular disease, substance abuse, or unmanaged psychiatric conditions

Important: Always verify eligibility with the trial site directly before applying.