Phase 2 Castleman Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 80 years old (male or female)
• You have been diagnosed with a condition called iMCD (idiopathic multicentric Castleman disease), confirmed by a specialist or through a related registry study
• Your iMCD has not responded well enough to a type of treatment called anti-IL-6 therapy, your symptoms came back while on that treatment, or you were unable to tolerate it
• You currently have signs of active disease, such as fatigue, night sweats, fever, or weight changes, along with certain abnormal blood test results and swollen lymph nodes
• You are able to swallow tablets
• You are able to give your informed consent before taking part in any study activities

Who may not be able to join:

• You are pregnant, breastfeeding, or unwilling to use effective contraception during the study and for at least 12 weeks after treatment ends
• You have received treatments for iMCD (other than steroids or anti-IL-6 therapy) within the past 14 days before joining, or your steroid dose was recently increased
• You have previously been treated with a drug called ruxolitinib for iMCD
• You have an uncontrolled or active infection, or an infectious disease that could be confused with iMCD
• Your general physical health or certain blood test results fall below the levels required (confirm with trial site for specific numbers)
• Your kidney function is significantly reduced, or certain liver enzymes are too high
• You have very low levels of red blood cells, white blood cells, or platelets (without recent transfusion)
• You have breathing problems related to lung involvement, or your blood oxygen level is too low
• Your fasting cholesterol or triglyceride (blood fat) levels are too high
• You have a rheumatologic (joint/immune) disease that could be confused with iMCD
• You have had a cancer diagnosis within the past year, unless it was a minor skin cancer or early-stage cervical cancer (other cancers may be considered if you have been cancer-free for over a year and your life expectancy exceeds five years — confirm with trial site)
• You have a documented history of HIV, a virus called HHV-8, or a severe immune deficiency condition
• You have an active tuberculosis, hepatitis B, or hepatitis C infection (some past or resolved cases may still be eligible — confirm with trial site)
• You have had a serious heart event such as a heart attack or stroke within the past 6 months
• You are currently in, or planning to join, another clinical trial involving iMCD treatment or immune-affecting therapies
• You have had a known allergic reaction to ruxolitinib or similar medications
• You have a serious medical or psychiatric condition that could interfere with your ability to complete the trial
• You have a psychiatric condition that prevents you from fully understanding and agreeing to take part
• The study doctor believes there is any other reason participation would not be appropriate for you

Important: Always verify eligibility with the trial site directly before applying.