COPD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have signed an informed consent form agreeing to take part
• People who have been diagnosed with COPD or emphysema
• People who are at least 22 years old
• People whose body mass index (a measure of height and weight) falls between 18 and 32
• People who can walk between 100 and 400 metres in a 6-minute walk test
• People whose COPD is currently stable and who are taking less than 10 mg of prednisone (or a similar medication) per day
• People who have not smoked, vaped, or used marijuana or any other tobacco or nicotine products for at least 4 months before their screening interview
• People whose lung function test (FEV1) result falls between 15% and 45% of the value expected for someone of their age and size
• People whose ratio of two lung function measurements (FEV1/FVC) is below 70%, indicating airflow limitation
• People whose CT scan shows that at least 25% of the tissue in each lung has been damaged by emphysema, as confirmed by a specialist imaging laboratory
• People whose CT scan shows that emphysema is present throughout both lungs (either evenly or unevenly), with at least one lung showing a 15% or greater difference in damage between the upper and lower sections, as confirmed by a specialist imaging laboratory
• People whose lungs hold significantly more air than normal after breathing out (residual volume greater than 175% of the expected value)
• People who rate their breathlessness at level 2 or higher on a standard breathlessness scale (mMRC score)

Who may not be able to join:

• People who are currently taking part in another clinical study that involves surgery, a medical procedure, or a medication treatment
• People who have a condition called alpha-1 antitrypsin deficiency, a genetic disorder that can cause lung disease
• People who are women of childbearing potential
• People who have been hospitalised for COPD flare-ups (exacerbations) more than twice in the year before screening
• People who have been hospitalised for a COPD flare-up within 6 weeks of the planned procedure
• People who have been hospitalised for pneumonia two or more times in the year before screening
• People who have significant ongoing mucus build-up or chronic bronchitis
• People who have had a heart attack, or have unstable or poorly controlled heart failure, within the 6 months before screening
• People who have previously had a lung transplant, lung volume reduction surgery, removal of lung tissue (bullectomy or lobectomy), or an endoscopic lung volume reduction procedure
• People who have a significant airway condition called bronchiectasis
• People who cannot safely stop taking blood thinners or platelet-inhibiting medications for 7 days
• People who have uncontrolled high blood pressure in the lungs, or a related heart condition called cor pulmonale, based on a recent heart ultrasound
• People who have a suspected or confirmed lung cancer or suspicious lung nodule
• People whose recent high-resolution CT scan shows any of the following: large air pockets (bullae) taking up more than 30% of either lung; images that cannot be properly assessed using the required software; or all lobes of the lungs showing less than 25% emphysema damage (confirm with trial site)
• People who have a heart condition that the treating doctor believes would make the procedure unsafe for them
• People whose total lung capacity is below 100% of the expected value at screening
• People whose lung gas transfer measurement (DLCO) is either below 15% or above 50% of the expected value at screening
• People whose blood carbon dioxide level is above a certain threshold (PaCO2 greater than 50 mm Hg) at screening
• People whose blood oxygen level while breathing normal room air is below a certain threshold (PaO2 less than 45 mm Hg) at screening
• People whose screening tests show cotinine levels (a marker of nicotine exposure) or carbon monoxide levels in the blood above the specified limits, which may indicate recent smoking or vaping
• People who currently have a diagnosed substance use disorder
• People who currently have a diagnosis of Major Depressive Disorder, Schizoaffective Disorder, Schizophrenia, Borderline Personality Disorder, or Bipolar Disorder
• People who have any other condition that the trial investigator believes would make participation unsafe or unsuitable

Important: Always verify eligibility with the trial site directly before applying.