Alzheimer's Disease Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People between the ages of 55 and 90 years old (inclusive).
- People who are willing and able to attend a starting assessment, provide biological samples (such as blood), share some personal information, and attend all follow-up visits over time.
- People who are able to have an MRI scan, with no medical reasons preventing this.
- People who fall into one of three cognitive groups:
- Cognitively Normal (CN): No memory complaints beyond what is expected for their age (confirmed by someone who knows them well); a score of 26–30 on a standard memory test (MMSE); no signs of memory or daily functioning problems.
- Mild Cognitive Impairment (MCI): The person, someone who knows them, or their doctor has noticed memory concerns; MMSE score in the same range as the CN group; some memory difficulties but general thinking and daily functioning are mostly preserved; does not meet the criteria for Alzheimer's disease.
- Alzheimer's Disease (AD): The person, someone who knows them, or their doctor has noticed memory concerns; MMSE score below 26; meets recognised medical diagnostic criteria for probable Alzheimer's disease, which may include specific scan or biological test results (confirm with trial site).
Who may not be able to join:
- People who have, or are found through MRI to have, major brain or neurological conditions other than Alzheimer's disease — such as stroke, epilepsy, Parkinson's disease, brain tumours, multiple sclerosis, or significant brain injury with lasting effects, among others.
- People with serious psychiatric conditions (such as schizophrenia requiring ongoing medication) or other known structural abnormalities in the brain.
- People with serious failure of major organs (such as the heart, liver, or kidneys), active cancer, or a health condition that makes it unlikely they would be able to complete all follow-up visits.
- People with medical reasons that prevent MRI scanning — for example, severe claustrophobia, a pacemaker that is not MRI-compatible, certain metal implants, an aneurysm clip, an artificial heart valve, or a cochlear implant.
- People whose medical history or examination findings are judged by the trial investigators to make MRI scanning or ongoing participation potentially unsafe (confirm with trial site).
- People who have used an experimental drug within one month before joining the trial, or who would need to use one during the trial.
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
GP referral letter
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Trial details
Where this trial is recruiting
Primary endpoints
Change from Baseline in Regional Brain Sodium Concentration (mmol/L) Measured by 7 T ²³Na-MRI; Change from Baseline in Resting-State Fractional Amplitude of Low-Frequency Fluctuations（fALFF, unitless) Measured by 7 T fMRI; Change from Baseline in Mean Apparent Diffusion Coefficient (ADC) (×10-³ mm²/s) Derived from Dynamic Diffusion-Weighted Imaging (DynDWI); Change From Baseline in Fractional Anisotropy (FA, unitless); Change From Baseline in Mean Diffusivity (MD, ×10-³ mm²/s)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 7 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.