Phase 1 Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with dementia according to the standard criteria set by the National Institute on Aging-Alzheimer's Association (NIA-AA).
• People whose dementia has been rated as a score of 3 on the Clinical Dementia Rating (CDR) scale, which indicates severe dementia.
• People who are able to walk on their own or with the help of a walker or cane.
• People who have enough vision and hearing to take part in examinations and treatment sessions.
• People who are willing to participate voluntarily, and where both the person and their legal guardian have signed a written consent form.

Who may not be able to join:

• People who have a pre-existing structural problem in the brain, such as a tumour, stroke damage, fluid build-up in the brain (hydrocephalus), or bleeding in the brain.
• People who also have another nervous system condition, such as multiple sclerosis, epilepsy, or Parkinson's disease.
• People who have a psychiatric condition such as anxiety, depression, other mood disorders, or psychosis related to drug use.
• People who have serious internal health conditions, are currently taking certain medications (including those for breathing, heart, seizures, or mental health), or have significant disease affecting the gut, kidneys, liver, lungs, immune system, hormones, or heart — or who have cancer, alcohol dependency, or substance addiction.
• People who have severe hearing or vision impairment.
• People who have another serious illness where life expectancy is estimated to be less than 2 years.
• People who have previously had surgery on the skull or brain.
• People for whom MRI scans or a type of brain stimulation called transcranial alternating current stimulation (tACS) are not safe — for example, those with a cardiac pacemaker or who have had deep brain stimulation surgery.
• People who have eczema or particularly sensitive skin.
• People who have the inherited (familial) form of Alzheimer's disease.
• People whose dementia is caused by something other than Alzheimer's disease, such as vascular dementia, Lewy body dementia, frontotemporal dementia, or dementia caused by infection.
• People whom the trial investigators consider unsuitable for the study for any other reason.

Important: Always verify eligibility with the trial site directly before applying.