Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 75 years old
• People who have been diagnosed with HER2-positive invasive breast cancer, confirmed through a tissue sample (biopsy), at specific stages of disease (not too early and not spread to distant parts of the body — confirm exact staging with the trial site)
• People whose cancer tests show HER2 overexpression, meaning the HER2 protein is strongly present or the HER2 gene is amplified, as measured by specific laboratory tests
• People whose heart is pumping blood effectively, with a heart function measurement (called LVEF) of 50% or higher
• People who are generally well enough to carry out daily activities, rated 0 or 1 on a standard health performance scale (meaning fully active or restricted in strenuous activity only)
• People whose blood test results show that the bone marrow, liver, and kidneys are functioning within acceptable ranges, without having needed blood transfusions or blood-boosting medications in the two weeks before starting the trial

Who may not be able to join:

• People with a previous history of invasive breast cancer
• People with cancer affecting both breasts, or a type called inflammatory breast cancer
• People who have already had surgery to remove or sample the main breast tumour or underarm lymph nodes
• People who have previously received any systemic treatment (such as chemotherapy or targeted therapy) for breast cancer
• People who have had a severe allergic reaction to any component of the investigational drug in the past, or who are known to be allergic to it
• People who have taken part in another clinical trial or received an experimental drug or device within the 4 weeks before starting this trial, or who would do so during this trial
• People who have had major surgery within 28 days before starting the trial, or who have major surgery planned during the study
• People who have had another type of cancer in the past 5 years, with some exceptions such as certain early-stage or skin cancers (confirm with trial site)
• People with active tuberculosis or serious infections requiring treatment throughout the body, such as severe pneumonia or blood infections
• People with a history of immune system conditions such as HIV, lupus, or rheumatoid arthritis, or who have had an organ transplant
• People with certain heart or brain blood vessel conditions, including unstable chest pain, significant heart rhythm problems requiring medication, a heart attack in the past 6 months, heart failure, significant heart conduction problems, or a stroke or brain bleed in the past 6 months
• People with poorly controlled high blood pressure despite taking medication, or a history of hypertensive crisis or brain complications from high blood pressure
• People who are unable to swallow or absorb oral medication, including those with significant digestive conditions such as intestinal blockage, Crohn's disease, or ulcerative colitis
• People who are pregnant, breastfeeding, have a positive pregnancy test at screening, or are unwilling to use effective contraception during the study and for 6 months after the last dose

Important: Always verify eligibility with the trial site directly before applying.