Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with Stage II or III breast cancer that has been confirmed by a tissue biopsy.
• Your breast cancer has been confirmed to be HER2-positive (a specific type of breast cancer identified through testing).
• The hormone receptor (HR) status of your breast cancer tumor has been tested and is known.
• If you have breast cancer in more than one area of the breast, you may still be eligible if the largest tumor is at least 2 cm wide, is HER2-positive, and your doctor has decided to treat it as HER2-positive.
• You are willing to have surgery (either full breast removal or a smaller, breast-saving surgery) after receiving treatment before surgery.
• You are generally able to carry out daily activities with little to no limitations (confirm with trial site).
• Your major organs (such as liver and kidneys) are working well enough as shown by recent blood tests.
• Your heart is pumping blood effectively — at least 50% efficiency — confirmed by a heart scan done within 4 weeks before starting the trial.
• You are using adequate birth control methods if applicable.

Who may not be able to join:

• Your breast cancer has spread to other parts of the body (Stage IV/metastatic).
• You have cancer in both breasts at the same time.
• You have a serious or uncontrolled health condition that the trial doctor feels could affect your participation.
• You have high blood pressure that is not well controlled.
• You have significant nerve problems in your hands or feet (such as numbness, tingling, or pain).
• You currently have an active infection that is not under control.
• You have previously had a severe, life-threatening allergic reaction to certain types of drugs similar to those used in this trial, including monoclonal antibodies or related proteins.
• You have an active hepatitis B or hepatitis C infection.
• You have been diagnosed with another cancer within the last 5 years (some exceptions apply, such as certain treated skin cancers — confirm with trial site).
• You have previously received chemotherapy, anti-HER2 treatment, radiation, hormone therapy, or experimental treatment for invasive breast cancer.
• You are planning to take part in another clinical trial or receive any other cancer treatment not included in this study's plan.
• You have received a live vaccine within the 4 weeks before enrolling in the trial.
• You have a known allergy to any of the medications used in this trial, including chemotherapy drugs.

Important: Always verify eligibility with the trial site directly before applying.