Phase 2 Stroke Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are 40 years old or older
- You have had a stroke (either a bleeding stroke or a blocked blood vessel stroke) in either side of the brain, and it happened at least 6 months ago
- You have been confirmed to have significant apathy (lack of motivation or interest) based on a standard questionnaire score — either completed by you or your caregiver
- You are able to take part in memory and thinking tests
- The area of your brain being targeted in this study is undamaged, as confirmed by an MRI scan before treatment
- You have a caregiver or support person who is able to take part in the study alongside you
Who may not be able to join:
- Your stroke was only a bleed around the outside of the brain (such as a subdural or subarachnoid hemorrhage) without any other type of stroke
- You have another brain or nervous system condition that affects your movement or thinking, such as dementia
- You have moderate or severe difficulty with language due to your stroke
- Your vision problems would prevent you from completing the thinking and memory tasks
- You have a medical implant that is not compatible with MRI or the brain stimulation used in this study, such as a pacemaker or certain metal implants
- You are pregnant, or if there is a chance you could be pregnant, this will be checked before you take part
- You have a history of seizures or epilepsy
- You have a wound, skin problem, bone defect, or a section of skull that was surgically removed on your scalp or head
- You feel very uncomfortable in enclosed spaces (claustrophobia) in a way that would stop you from having an MRI scan
- You are currently struggling with a substance use disorder (such as alcohol or drug dependency)
- You have a condition involving psychosis
- You have Bipolar 1 Disorder
- You are currently having thoughts of suicide or have made a suicide attempt in the past year
For the caregiver/support person — who can take part:
- They are 18 years old or older
- They are in regular contact with you at least once a week and can give reliable information about how you are thinking and managing day-to-day life
- They are able to take part in the parts of the study that require their involvement (if they cannot engage with these, they may not be eligible)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Parneet Grewal, PhD, Medical University of South Carolina
Phone: 843-792-3020
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in apathy symptoms, as measured by the Lille Apathy Rating Scale (LARS) compared to baseline; Change in apathy symptoms as measured by the Apathy Evaluation Scale (AES) - Self and Informant Versions; Incidence of Treatment-Emergent Adverse Events and Side Effects as assessed by change in the Review of Systems Criteria compared to baseline; Change From Baseline Cognition, as Measured by the Fluid Cognition Composite Score From the NIH Toolbox Cognition Battery compared to baseline; Participant retention rate; Patient perception of treatment acceptability as assessed by study-specific que...
Can't join this trial?
Data last synced from ClinicalTrials.gov: 9 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.