Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 18 and 75 years old
• People whose condition meets current medical guidelines for a procedure called mechanical thrombectomy (a treatment to remove a blood clot from a brain artery)
• People who were largely independent in daily life before their stroke (a low disability score of 2 or less on a standard scale)
• People whose brain scan shows a score of 6 or higher on a measure called ASPECTS, which indicates how much of the brain has been affected
• People who have a blockage in a specific brain artery called the middle cerebral artery (MCA), with or without a blockage in the connected artery called the ICA
• People whose mechanical thrombectomy procedure was not successful, meaning little or no blood flow was restored
• People for whom brain surgery (craniotomy) is expected to take place within 24 hours of when the stroke began
• People who had a stroke that was discovered upon waking, where brain scans show there is still salvageable brain tissue surrounding the damaged area

Who may not be able to join:

• People who have certain blood vessel conditions in the brain, such as an aneurysm or abnormal blood vessel formation, or who are already planned for a brain blood vessel surgery
• People who have had unstable chest pain, a heart attack, or heart failure in the past 6 months
• People who are pregnant or in the period shortly after giving birth
• People who have a blood disorder that affects how their blood clots
• People who have another serious illness where life expectancy is estimated to be less than 2 years
• People who have previously had bypass surgery on blood vessels in or around the brain
• People who are allergic to iodine or X-ray contrast dye, have significantly reduced kidney function (creatinine above 3.0 mg/dl), or have other reasons they cannot safely undergo an arterial imaging procedure
• People with poorly controlled diabetes where fasting blood sugar is above a certain high level (16.7 mmol/L)
• People with poorly controlled high blood pressure above specific thresholds (sitting systolic above 180 mmHg or sitting diastolic above 110 mmHg)
• People with severe liver problems, shown by certain liver enzyme levels being more than 3 times above the normal range
• People with a low platelet count in their blood (below 100×10⁹/L), which can affect clotting
• People who have taken part in another clinical trial or used a trial drug or device within the past 30 days, or who are currently in another clinical trial
• People for whom general anaesthesia or brain surgery is not considered safe
• People with any other condition or medical history that the trial doctors believe could affect the safety or results of the study (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.