Crohn's Disease and Colitis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who currently eat fewer than 3 servings of fruits and vegetables per day (a low-polyphenol and low-fiber diet)
• People with mild-to-moderate ulcerative colitis (UC) at the time of screening, based on a standard scoring tool called the partial Mayo score (score between 2 and 5)
• People with biopsy-confirmed UC who also have signs of active inflammation, shown by specific blood, stool, or endoscopy results (confirm with trial site)
• People taking a medication called 5-aminosalicylate who have been on a stable dose for at least 4 weeks before screening
• People taking immune-suppressing medications (such as azathioprine, 6-mercaptopurine, or methotrexate) who have been on a stable dose for at least 8 weeks before the baseline visit
• People taking steroid medications, provided the dose is no more than 20 mg/day of prednisone or 9 mg/day of budesonide MMX at the time of the baseline visit
• People who are able to read, understand, and sign a written consent form before any study procedures begin

Who may not be able to join:

• People who do not speak English
• People who follow a vegetarian or vegan diet
• People with a known allergy to pomegranate
• People with a diagnosed chronic condition other than UC, including diabetes, kidney or liver disease, metabolic syndrome, active cancer, history of heart attack or stroke, or history of gastric bypass surgery
• People with Crohn's disease, indeterminate colitis, or severe to fulminant (very serious) colitis
• People who have had their colon surgically removed (colectomy) or who have a history of abnormal pre-cancerous cell changes in the colon (colonic dysplasia)
• People who have an ileal pouch or an ostomy (a surgically created opening in the abdomen)
• People with signs of an active bacterial or viral gut infection, based on stool test results
• People who were hospitalised for UC and needed intravenous (IV) steroids within 2 weeks before screening
• People whose blood test results suggest severe colitis, specifically a haemoglobin level below 8.0 g/dl or an albumin level below 3.0 g/dl
• People who have used antibiotics in the 3 months before screening, or who are currently using anti-diarrhoeal medications
• People taking supplements that may affect gut bacteria or metabolism (such as probiotics or fibre supplements), unless they are willing to stop taking them for the full duration of the study
• People currently using Total Parenteral Nutrition (nutrition delivered directly into the bloodstream)
• People who have used the medications cyclosporine, tacrolimus, or thalidomide within 2 months before screening
• People currently taking hormone therapies (such as hormone replacement therapy)
• People whose weight has changed by more than 10% in the last 6 months
• People who smoke or who live with someone who smokes
• People who drink more than 20 grams of alcohol per day
• People who are unwilling or unable to follow the study rules, including avoiding watermelon and other foods high in lycopene for the entire study period
• People who are unable to give informed consent

Important: Always verify eligibility with the trial site directly before applying.