Phase 1 Motor Neurone Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 75 years old (including those ages exactly)
• You have been diagnosed with ALS (either "definite" or "probable") based on a specific set of recognised diagnostic guidelines
• Your lung breathing capacity (measured by a breathing test called FVC) is at least 70% of the normal expected value for someone your age and size
• If you are able to father or carry a child, you must agree to use effective non-hormonal contraception from signing the consent form until 6 months after the trial ends
• You are willing to take part voluntarily and are able to read and sign a consent form

Who may not be able to join:

• You have muscle weakness that may be caused by something other than ALS
• Your body mass index (a measure of body weight relative to height) is below 18.5, meaning you may be considered underweight
• You have a condition called primary lateral sclerosis where only the upper part of your nervous system is affected
• You have a significant mental health condition that the doctor feels could affect the trial results
• You have another disease affecting your nerves or muscles, such as myasthenia gravis or a metabolic muscle condition
• You have an autoimmune disease with severe uncontrolled joint problems or other issues that the doctor feels could affect the trial results
• You had a serious infection requiring prescription medication (antibiotics, antivirals, or antifungals) within the 2 weeks before your screening appointment, and it is not yet under control
• You have been diagnosed with active tuberculosis (TB) or have been treated for suspected TB
• You have a serious lung disease that the doctor feels could affect the trial results
• You have high blood pressure that is not well controlled
• You have had or currently have any heart problems (confirm with trial site)
• You have a history of liver cirrhosis, long-term hepatitis, or abnormal liver function results at screening (confirm with trial site)
• You have a history of chronic kidney disease
• You have a history of abnormal bleeding or blood clotting, or you are currently taking blood-thinning medication
• You tested positive at screening for active hepatitis B, active hepatitis C, HIV, or syphilis
• You have had a serious injury or surgery that the doctor feels could affect the trial results
• You have a condition that makes a lumbar puncture (spinal tap) unsafe for you, such as an infection near the injection site or raised pressure in your skull
• You have had a cancer diagnosis within the past 5 years, or you are currently receiving cancer treatment
• You have taken part in another clinical trial within the 3 months before your screening appointment
• You are currently pregnant or breastfeeding
• The trial doctor has another reason they feel you are not suitable for this trial (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.