Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who had little to no disability before their stroke (able to live independently or with minor symptoms beforehand)
• People where treatment can begin within 24 hours of when they were last known to be well, including strokes noticed upon waking or strokes where no one saw them start
• People aged 18 to 75 years old
• People with a confirmed blockage in a specific major brain artery (the internal carotid artery or the main branch of the middle cerebral artery), confirmed by a specialised scan; people with certain nearby artery involvement may also be considered
• People who show at least some reduced level of alertness that is not caused by brain swelling
• People whose brain scans show either a very low brain tissue health score (ASPECTS 0–2), or a low score (ASPECTS 3–5) combined with a very high stroke severity score (NIHSS 30 or above)
• People whose brain scans show that at least half of the middle cerebral artery territory of the brain has been affected by the stroke
• People with no significant midline shift (the brain has not shifted more than 5mm to one side) on their scan
• People who have undergone a clot removal procedure (mechanical thrombectomy) with successful restoration of blood flow
• People where a specific skull surgery (decompressive hemicraniectomy) can be started within 6 hours after the clot removal procedure and within 4 hours after being enrolled in the trial
• People (or their legal representative) who have given informed consent to participate

Who may not be able to join:

• People showing signs of brain herniation (such as unequal pupil sizes or unstable vital signs) before being enrolled
• People where the treating doctor believes life-sustaining care is likely to be withdrawn within the first day
• People who have already been committed to skull decompression surgery before enrolment
• People with severely and persistently high blood pressure (systolic above 220 mmHg or diastolic above 110 mmHg)
• People with blood sugar levels that are very low or very high at the start of the study
• People with a low platelet count in their blood at the start of the study
• People with known bleeding disorders, clotting factor deficiencies, or who are on blood-thinning medication with a clotting measurement above a certain level
• People with severe kidney disease or those already on dialysis
• People who are unlikely to be able to complete a 90-day follow-up (for example, those without a fixed address or those living overseas)
• People where vasculitis (blood vessel inflammation) or infection-related clots are suspected as the cause of the stroke
• People with pre-existing neurological or mental health conditions that would affect assessment of their stroke
• People who are pregnant or breastfeeding
• People already participating in another clinical trial that could affect how results are assessed
• People who, in the treating doctor's judgement, have a life expectancy of less than 3 months due to conditions unrelated to the current stroke, or who are unlikely to follow up as required; other conditions the investigators consider unsuitable or high risk may also apply (confirm with trial site)
• People with evidence of other existing brain conditions such as a brain injury, brain tumour (except a small, specific type), or brain aneurysm on their scans
• People with evidence of stroke affecting both sides of the brain's front circulation, or involving the back of the brain (with some specific exceptions)
• People who experienced a blood vessel injury during the clot removal procedure
• People whose scans before enrolment show certain types of bleeding in or around the brain; people with only minor or localised bleeding of specific types may still be considered (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.