COPD Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with COPD or emphysema
• People who are at least 22 years old
• People with a body mass index (BMI) between 18 and 32
• People who are able to walk between 100 and 400 metres in a 6-minute walk test at the baseline exam
• People whose condition is stable and who are taking less than 10mg of prednisone (or an equivalent steroid) per day
• People who have not smoked — including tobacco, vaping, or marijuana — for at least 4 months before the screening interview
• People whose lung function test results (FEV1) fall between 15% and 50% of the expected value, and whose FEV1/FVC ratio is below 70%
• People whose CT scan shows that at least 25% of the lung tissue in each lung is damaged by emphysema
• People whose CT scan shows a particular pattern of emphysema (either evenly or unevenly spread), where at least one lung has a significant difference in damage between the upper and lower sections
• People whose lungs are significantly overinflated, as shown by a residual volume (RV) greater than 175% of the expected value
• People who score 2 or higher on the mMRC breathlessness scale, meaning their breathing difficulty noticeably affects daily activities
• People who have signed an informed consent form agreeing to take part

Who may not be able to join:

• People who are currently taking part in another clinical study involving surgery, a procedure, or medication
• People whose emphysema is caused by a condition called alpha-1 antitrypsin deficiency
• People who are women of childbearing potential
• People who have been hospitalised for COPD flare-ups more than twice in the year before screening
• People who have been hospitalised for a COPD flare-up within 6 weeks of the planned procedure
• People who have had two or more pneumonia episodes requiring hospitalisation in the past year
• People with significant ongoing mucus production or chronic bronchitis
• People who have had a heart attack, or have unstable or uncontrolled heart failure, within the 6 months before screening
• People who have previously had a lung transplant, lung volume reduction surgery, or any surgical or endoscopic procedure to reduce lung volume
• People with a significant airway condition called bronchiectasis
• People who are unable to safely stop taking blood thinners or anti-clotting medications for 7 days
• People with uncontrolled high blood pressure in the lungs, or a related heart condition called cor pulmonale, based on a recent heart ultrasound (confirm with trial site)
• People with a suspected lung tumour or lung cancer
• People whose CT scan shows large air pockets (bullae) taking up more than 30% of either lung, insufficient detail for the required analysis software, or all lung sections showing less than 25% disease damage
• People with a heart condition that the lead doctor (principal investigator) believes would make the procedure unsafe
• People whose total lung capacity (TLC) is below 100% of the expected value
• People whose lung gas transfer measurement (DLCO) is below 15% or above 50% of the expected value
• People with carbon dioxide levels in the blood above a certain threshold at screening (confirm with trial site)
• People with oxygen levels in the blood below a certain threshold while breathing room air at screening (confirm with trial site)
• People whose screening results indicate they may still be smoking (based on cotinine or carboxyhemoglobin levels)
• People who currently have a diagnosed substance use disorder
• People currently diagnosed with Major Depressive Disorder, Schizoaffective Disorder, Schizophrenia, Borderline Personality Disorder, or Bipolar Disorder
• People with any other condition that the investigating doctor believes would make participation unsafe or unsuitable

Important: Always verify eligibility with the trial site directly before applying.