Phase 3 Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 or older
• People who have a confirmed blockage in a major blood vessel supplying the front part of the brain (specifically the internal carotid artery or a main branch of the middle cerebral artery), confirmed by a specialised type of scan (CTA or MRA)
• People for whom a procedure to remove the blood clot is considered appropriate within 12 hours of symptoms starting
• People whose stroke is strongly suspected to be caused by a build-up of fatty deposits (plaque) in the arteries, based on their medical history, symptoms, and scan results
• People with a stroke severity score of 6 or higher on a standard medical scale (NIHSS) at the start
• People whose brain scan shows a score of 6 or higher on a measure of how much brain tissue is still healthy (ASPECTS)
• People who were largely independent in daily life before the stroke (a functional score of 2 or less on a standard scale called the mRS)
• People (or their legal representative) who have signed a consent form agreeing to take part

Who may not be able to join:

• People who have a history of irregular heart rhythms called atrial fibrillation or atrial flutter, or whose heart tracing (ECG) shows these rhythms after admission
• People who have had a bleeding-type stroke (such as a brain bleed or bleeding around the brain), or any bleeding event in the past month
• People who have brain aneurysms, abnormal blood vessel formations in the brain, very twisted arteries that would make the clot-removal procedure difficult, or brain tumours that are causing pressure in the skull
• People who have taken certain blood-thinning or antiplatelet medications in the past week, including dual antiplatelet therapy, direct oral anticoagulants, or warfarin
• People with severely uncontrolled high blood pressure (top number above 200 mmHg or bottom number above 110 mmHg)
• People with certain blood clotting problems, a key clotting measurement (INR) above 1.7, or a low platelet count (below 90×10⁹/L)
• People with severe kidney problems or a serious illness where life expectancy is less than 6 months
• People who are pregnant or breastfeeding
• People with known allergies to medications or contrast dyes used in scans
• People already taking part in another clinical trial
• People whom the research team considers unsuitable for other reasons (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.