Phase 3 Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 80 years old
• People whose stroke symptoms started no more than 24 hours before being enrolled in the trial
• People who have had a stroke caused by a blockage in a major blood vessel at the front of the brain, confirmed by a specialised brain scan (such as CTA, MRA, or DSA)
• People whose stroke symptoms are linked to that specific blocked blood vessel
• People with a stroke severity score (called NIHSS) of 6 points or higher, indicating a moderate to severe stroke
• People whose brain scan (NCCT) shows an ASPECTS score of 3 or higher, which is a measure of how much brain tissue has been affected
• People who have already had a successful procedure to remove the blood clot from the blocked vessel (called endovascular thrombectomy), with a good result on a standard medical scale
• People, or their family members, who have signed a written consent form agreeing to take part

Who may not be able to join:

• People who have bleeding in the brain, confirmed by a CT or MRI scan
• People who already had some level of disability before the stroke (a pre-stroke disability score of 2 or higher on a standard scale)
• People who are pregnant or breastfeeding
• People with a known allergy to iodine-based contrast dye, or to the medication methylprednisolone sodium succinate
• People who are already taking part in another clinical trial
• People with a blood clotting disorder (either inherited or acquired), or who are taking blood-thinning medication with a clotting measure (INR) above 1.7
• People who have had a major bleeding episode in the past month, such as bleeding in the stomach, bowel, or urinary tract
• People on regular kidney dialysis, or with severely reduced kidney function (based on specific blood or filtration measurements)
• People with a terminal illness where life expectancy is less than 6 months
• People with blood sugar levels that are either too low (below 2.8 mmol/L) or too high (above 22.2 mmol/L)
• People found to have a brain aneurysm, an abnormal tangle of blood vessels (arteriovenous malformation), or a brain tumour that is pressing on surrounding brain tissue
• People with an active infection anywhere in the body
• People who are unlikely to be able to complete the required follow-up appointments
• People in whom a scan during the clot-removal procedure showed a blood vessel tear, puncture, or leakage of dye
• People whose clot-removal procedure took longer than 90 minutes from first access to reopening the vessel, or required more than 3 attempts to remove the clot

Important: Always verify eligibility with the trial site directly before applying.