Prostate Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are a male aged 18 or older
• A biopsy has confirmed prostate cancer that has come back inside the prostate after you previously received external beam radiation therapy (a type of radiotherapy)
• Your biopsy results show active, living cancer cells that can be graded by a pathologist (using something called a Gleason score)
• Your testosterone level is at or above 50 ng/dL, tested within the last 2 months before joining (previous hormone therapy is okay as long as your testosterone is currently above this level)
• At least 4 weeks have passed since any major surgery
• You are generally in good health and able to carry out most normal daily activities (confirm with trial site)
• Your prostate is smaller than 90 cc in size, as measured by an MRI scan
• Your urinary symptom score (a standard questionnaire about bladder and urination) is 20 or below
• You are able and willing to attend follow-up appointments for at least 2 years, and be contactable for up to 5 years
• An MRI scan shows a visible area of concern within your prostate
• You are willing and able to have an MRI scan and complete the standard MRI safety screening form

Who may not be able to join:

• You have previously had brachytherapy (internal radiation seeds or implants) for prostate cancer
• You are currently receiving hormone therapy (such as androgen deprivation therapy) or anti-androgen medications
• Scans (CT, MRI, or PET) show that cancer has spread outside the prostate
• Scans suggest that one or more lymph nodes may be affected by cancer
• You have had another cancer in the past 2 years, unless it was certain types of treated skin cancer, a superficial bladder cancer, or another cancer that has been fully in remission for at least 3 years
• You have Crohn's disease or ulcerative colitis
• You are unable to have an MRI scan for reasons such as having a pacemaker, a defibrillator, certain metal implants or electronic devices in your body, severe claustrophobia, or being unable to lie flat for the length of the scan
• You have a metal implant or device in your pelvis area that could interfere with MRI image quality
• Your body size does not meet the specific measurements required for a particular type of MRI imaging used in this trial (confirm with trial site)
• You have a known allergy or medical reason preventing you from receiving gadolinium contrast dye or a specific type of imaging agent used in PET scans
• Your general health and ability to perform daily activities falls below the required level
• You experienced severe side effects (grade 3 or higher) from your original course of radiotherapy
• Less than 2 years have passed since your prostate cancer was last treated or considered under control
• You had a procedure called TURP (a surgical treatment for urinary problems involving the prostate) within the last year
• You have previously had HIFU (high-intensity focused ultrasound) or cryotherapy treatment for prostate cancer
• You have a history of urethral stricture (narrowing of the tube you urinate through)
• You are not able to give informed consent to take part in the trial
• You are not able to complete quality of life questionnaires

Important: Always verify eligibility with the trial site directly before applying.