Phase 3 Osteoarthritis Trial, Recruiting NCT07153471 Sponsor: Eli Lilly and Company Condition: Osteoarthritis
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Phase 3 Osteoarthritis Trial, Recruiting

NCT07153471
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • Your Body Mass Index (BMI) is 27 or higher (a measure of body weight relative to height)
  • You have tried at least one diet to lose weight in the past, but it did not work
  • You have been diagnosed with osteoarthritis of the knee, AND at least one of the following applies to you:
    • You are over 50 years old
    • Your knees feel stiff in the morning for around 30 minutes
    • You feel or hear a crackling or grinding sensation in your knee

Who may not be able to join:

  • Your weight has changed by more than 11 pounds (either gained or lost) in the last 90 days
  • You have had weight-loss surgery in the past, or are planning to have it within the next 18 months
  • You currently have an active infection in your knee
  • You have any form of diabetes, including type 1 or type 2
  • You have recently had a serious heart condition, or have been diagnosed with severe heart failure (confirm with trial site)
  • You have taken a GLP-1 medication (a type of weight or blood sugar medicine, such as semaglutide or liraglutide) within the last 180 days

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 26 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Phone: 1-317-615-4559

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Registry
ClinicalTrials.gov
Start date
15 September 2025
Est. completion
1 April 2028

Where this trial is recruiting

🇨🇦 Canada 🇨🇳 China 🇩🇪 Germany 🇮🇳 India 🇯🇵 Japan 🇲🇽 Mexico 🇪🇸 Spain 🇺🇸 United States

Primary endpoints

Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 26 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov