Phase 2 Macular Degeneration Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have signed a consent form before the screening process begins
• Men or women aged between 50 and 85 years old at the time of signing the consent form
• People who have geographic atrophy (a form of damage to the central part of the retina) affecting the central area of the eye, caused by dry age-related macular degeneration (AMD)
• People whose area of retinal damage falls within a specific size range — not too small and not too large — as measured by specialised eye imaging software
• People whose retinal damage, if it appears in more than one patch, includes at least one patch large enough to measure treatment effects
• People whose combined areas of retinal damage together meet the required size range
• People whose retinal damage is located within a certain distance of the central point of the retina
• People whose area of retinal damage can be fully captured in an eye photograph
• People whose vision in the study eye falls within a specific range on a standard eye chart (roughly, being able to read between a certain level of clarity and a certain level of blur)
• People who have sufficiently clear eyes and pupils that can dilate well enough for all required imaging procedures
• People who use the centre of their vision (rather than a shifted area) for focusing

Who may not be able to join:

• People who have previously had radiation therapy in the area of the study eye
• People who have previously received any gene therapy treatment, whether for the eye or elsewhere in the body
• People who have taken part in any other clinical trial using an investigational treatment within the past 60 days
• Women who are currently pregnant or breastfeeding
• People with a known allergy or sensitivity to eye-numbing drops or diagnostic eye drops used in the study
• People with any other health condition that, in the doctor's judgement, could interfere with following the study procedures, raise safety concerns, or affect the reliability of results
• People whose vision test results varied by more than 30% between two measurements taken at least 14 days apart during screening
• People who have had eye surgery or laser treatment within the 3 months before joining, or any laser treatment to the central area of the retina at any point in the past
• People who have had an eye or eyelid infection, or eye surface inflammation, within the past 12 weeks
• People who have had certain previous eye procedures, including surgery on the gel inside the eye, certain glaucoma surgeries or devices, corneal transplant, or retinal detachment surgery
• People who have any signs of diabetic eye disease in either eye
• People with eye pressure above 25 mmHg in either eye
• People whose retinal damage has completely destroyed a specific layer of the retina at the central location, as seen on a detailed eye scan (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.