Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with an acute stroke caused by reduced blood flow to the brain, or a sudden loss of blood supply to the eye, within the last two weeks
• People whose stroke or eye event appears to be linked to a specific type of fatty deposit (plaque) in the carotid artery on the same side as the affected area, where the plaque is causing a 10–49% narrowing of the artery
• People where no other clear cause for the stroke has been found (such as a heart or large blood vessel source), based on standard heart and blood vessel tests
• People whose carotid artery plaque shows high-risk features on a CT scan or MRI — specifically, at least two of the following: plaque thickness of 3mm or more, irregular plaque surface, ulceration, less than 50% calcification, or a fatty core; OR at least one of the following: bleeding within the plaque
• People whose carotid artery shows a specific shelf-like or smooth ridge-like abnormality known as a carotid web
• People whose plaque imaging results have been reviewed and confirmed by an independent review centre
• People aged 18 or older
• People whose level of physical disability at the time of joining the trial is mild to moderate (confirm with trial site)
• People who are already receiving dual antiplatelet therapy (two types of blood-thinning medication) as part of their standard care before any procedure

Who may not be able to join:

• People who have a complete blockage of the carotid artery requiring emergency treatment
• People whose stroke involved blood vessel territories other than the carotid artery on the affected side
• People whose stroke is likely to have been caused by small vessel disease, major artery narrowing of 50% or more, a clot from the heart, or another known condition such as blood vessel inflammation
• People whose plaque is made up of 50% or more calcium deposits, as seen on CT scan
• People who have a blood clot sitting inside the carotid artery
• People whose blood vessels are very curved or twisted (more than 90 degrees), which may make safe placement of a stent difficult
• People who have previously had a carotid surgery or stent procedure and have developed narrowing again at the same site
• People with blood clotting disorders
• People for whom reaching the affected area of the carotid artery is not possible, or carries a higher than acceptable risk
• People whose plaque is located at the very beginning (opening) of the main carotid artery
• People with a known allergy to nickel-titanium (the material used in the stent)
• People with a known allergy to heparin (a blood-thinning medication)
• People with any condition that reduces life expectancy to less than 12 months
• People with any condition that increases the risk of endovascular (stent-based) procedures
• People who would not be able to attend follow-up clinic visits each year

Important: Always verify eligibility with the trial site directly before applying.