Phase 3 Vasculitis Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- You are between 18 and 75 years old (male or female)
- You have been diagnosed with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) — these are conditions where the immune system attacks blood vessels
- You have been newly diagnosed or have had a return of GPA or MPA that needs treatment with steroids plus certain other medicines (cyclophosphamide, azathioprine, or rituximab)
- Your blood test shows positive results for certain antibodies linked to these conditions (called PR3 or MPO antibodies)
- Your kidneys are working at a minimum level, as measured by a standard kidney function test (eGFR of at least 15 mL/min/1.73m²)
- Your disease is active enough to meet a minimum score on a standard disease activity assessment used by doctors (called BVAS) (confirm with trial site)
Who may not be able to join:
- You currently have an active tuberculosis (TB) infection
- You have severe lung bleeding that requires the use of a breathing machine (ventilator)
- You have been diagnosed with most types of cancer in the last 5 years — though certain fully removed skin or in-situ cancers with no signs of return may be acceptable (confirm with trial site)
- You have another autoimmune disease affecting multiple parts of the body, such as lupus, rheumatoid vasculitis, or several other related conditions
- You have tested positive for certain markers of hepatitis B infection in your blood
- You have received certain medicines too recently — for example, cyclophosphamide within the last 3 months, or rituximab within the last 12 months
- You have received high-dose steroid "pulse" treatment in the last 4 weeks
- You have been taking oral steroids at a dose higher than 10 mg prednisone (or equivalent) every day for more than 6 weeks continuously before joining
- You have received certain biological (anti-TNF or similar) treatments within the last 12 weeks
- You have been on long-term dialysis (12 weeks or more), or had any dialysis within the last week
- You have received intravenous immunoglobulin or plasma exchange treatment within the last 4 weeks
- You are currently pregnant or breastfeeding
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Minghui Zhao, M.D., Peking University First Hospital
Phone: +86 010-67519614
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
The proportion of patients achieving disease remission assessed by Birmingham Vasculitis Activity Score (BVAS)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 28 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.