Pulmonary Hypertension Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

People with biliary tract cancer (internal training/validation group):

• People aged 18 to 80 who have been diagnosed with biliary tract cancer (any stage) confirmed by a pathologist, are generally well enough to carry out basic daily activities, and have blood test results showing the liver, kidneys, and blood counts are within acceptable ranges.

People with other digestive system cancers (comparison group):

• People aged 18 to 80 who have been diagnosed with a gastrointestinal cancer other than biliary tract cancer — such as liver, stomach, bowel, or pancreatic cancer (any stage) — and are generally well enough to carry out basic daily activities.

People with non-cancerous bile duct or gallbladder conditions (comparison group):

• People aged 18 to 80 who have been diagnosed with a benign (non-cancerous) condition affecting the gallbladder or bile ducts, such as gallstones, gallbladder polyps, inflammation of the gallbladder, or primary sclerosing cholangitis.

People with suspected biliary tract cancer (external validation group):

• People aged 18 to 80 whose scans or blood tests strongly suggest biliary tract cancer, and who are already scheduled for surgery or a biopsy to confirm the diagnosis, and whose organ function blood results are within acceptable ranges.

Healthy volunteers (external validation group):

• People aged 18 to 80 with no cancer history who are able to provide blood samples and give their consent to participate.

All groups require participants to be willing to take part, able to follow the study procedures, and able to provide the required blood samples. Consent may be given by a legally authorised representative if the participant is unable to sign.

Who may not be able to join:

Cancer participants:

• Women who are pregnant or breastfeeding.
• People who have had an organ transplant or a bone marrow or stem cell transplant from a donor.
• People who received a blood transfusion within 7 days before the blood sample is taken.
• People who received curative cancer treatment within the past 3 years (or are currently undergoing such treatment, in the external validation group).
• People who have taken anti-cancer drugs within the past 30 days before the blood sample is taken.
• People with a known bleeding disorder.
• People with a known autoimmune disease.
• People who have more than one active cancer at the same time, or more than one primary cancer.
• For the external validation group: people whose biopsy or surgery confirms a benign (non-cancerous) condition, people who carry known cancer-risk gene variants, or people whose cancer cannot be confirmed within 42 days of the blood sample being taken.
• For the external validation group: people who have already received any cancer treatment — including surgery, radiotherapy, targeted therapy, or immunotherapy — before the blood sample is taken, or whose biopsy confirms only a pre-cancerous lesion.

Non-cancer participants and healthy volunteers:

• Women who are pregnant or breastfeeding.
• People who have had an organ transplant or a bone marrow or stem cell transplant from a donor.
• People who received a blood transfusion within 7 days before the blood sample is taken.
• People with any history of cancer.
• People with a known bleeding disorder or autoimmune disease.
• People with significant abnormalities found on a routine health check (minor findings such as hepatitis, liver cysts, or small benign lung nodules may not necessarily exclude someone — confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.