Phase 3 Schizophrenia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years old or older.
• If you are female, you have a negative pregnancy test at the start of the study, are not breastfeeding, and agree to use appropriate birth control (unless you cannot become pregnant).
• You have been diagnosed with schizophrenia according to current medical guidelines (DSM-5-TR).
• Your schizophrenia has not responded well enough to antipsychotic medications, meeting a specific definition of treatment-resistance (confirm with trial site).
• You are currently taking one or more antipsychotic medications at a recommended therapeutic dose as part of your regular care.
• Your illness is rated at least "mildly ill" or worse on a standard medical assessment scale at the start of the study.
• Your symptom scores on standard psychiatric rating scales (BPRS and PANSS) are above certain set thresholds at the start of the study (confirm with trial site).
• Your overall daily functioning is significantly impaired, as measured by a standard scale (confirm with trial site).
• You are consistently taking your prescribed antipsychotic medication as directed.
• You have given your written agreement to take part in the study before it begins.

Who may not be able to join:

• You have a diagnosis of a related but different condition, such as schizophreniform disorder, schizoaffective disorder, bipolar disorder, or major depressive disorder.
• You have been diagnosed with a substance use disorder in the past three months, or currently have one.
• Your current symptoms are so severe that you need to be hospitalised to stabilise them — unless your medication dose has been stable for at least 6 weeks before the study screening.
• You have a history of, or are currently diagnosed with, other psychiatric or behavioural disorders.
• You are considered to be at known risk of suicide, or you have made a suicide attempt in the past 2 years.
• You have a history of a serious reaction to antipsychotic medication called neuroleptic malignant syndrome, or a condition called priapism.
• You have any other health condition that could affect your safety or interfere with the study results (confirm with trial site).
• You have a history of epilepsy or seizures, have had a seizure in the past year, or have had repeated seizures caused by drugs.

Important: Always verify eligibility with the trial site directly before applying.