Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged over 18 years
• People who have had a blockage or severe narrowing (70% or more) detected in certain medium-sized blood vessels in the brain, confirmed by a specialised brain scan (such as a CTA, MRA, or DSA), affecting specific arteries in the middle, front, back, or lower parts of the brain
• People whose stroke symptoms match the type of blockage identified, with a stroke severity score (called NIHSS) between 5 and 25, or between 3 and 4 if the symptoms are significantly disabling — such as loss of vision in part of the visual field, difficulty speaking, or weakness
• People who are able to receive a clot-dissolving treatment delivered directly into the artery within 24 hours of stroke symptoms starting (or of when they were last known to be well), provided there is no obvious area of dead brain tissue on a standard CT scan and blood flow through alternative vessels appears adequate
• People whose stroke onset was between 24 and 72 hours ago, provided that specific brain imaging shows a pattern suggesting there is still brain tissue that could potentially be saved — either through a perfusion scan showing a small area of damage with a larger area at risk, or through an MRI showing a mismatch between two different types of scan sequences (confirm with trial site for full imaging details)
• People who have given their signed consent to take part

Who may not be able to join:

• People who had some degree of disability before the stroke, based on a standard disability scale (called the modified Rankin Scale, or mRS) with a score of 2 or higher
• People whose blood vessel blockage or narrowing was caused by a previous procedure inside the blood vessel
• People whose brain scans show any form of bleeding in or around the brain
• People whose standard CT scan shows a clearly visible area of dead brain tissue in the affected region
• People with a low platelet count (below 100 × 10⁹/L), a known tendency to bleed, a known clotting factor problem, or who are on blood-thinning medication with a clotting test result (INR) above 3.0
• People with persistently high blood pressure that cannot be brought under control — specifically, a top number above 185 mmHg or a bottom number above 110 mmHg
• People who have had any type of bleeding inside the skull within the past 3 months
• People who have an abnormal tangle of blood vessels (arteriovenous malformation) or a brain tumour that is causing pressure in the brain
• People who have had bleeding in the digestive system or urinary tract, or who have had major surgery, within the past 3 months
• People on long-term kidney dialysis, or with severely reduced kidney function (based on specific kidney function test results — confirm with trial site)
• People with a known allergy to clot-dissolving medications or their ingredients
• People with a known allergy to the dye used in certain scans (iodinated contrast), or other established reasons these cannot be used
• People who are pregnant or currently breastfeeding
• People with serious health conditions in other parts of the body where life expectancy is estimated to be less than 3 months
• People considered unsuitable for any other reason by the doctor running the trial

Important: Always verify eligibility with the trial site directly before applying.