Phase 2 Macular Degeneration Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 50 and 80 years old (for Phase I) or between 50 and 85 years old (for Phase II) at the time of signing the consent form, and you are male or female
• You have been diagnosed with active abnormal blood vessel growth under the retina (called choroidal neovascularization, or CNV) caused by age-related macular degeneration (AMD), confirmed by special eye imaging tests
• The affected area in your eye is below a certain size limit, as measured by an eye imaging test called fluorescein angiography
• You have either never been treated for this condition before, or you previously received anti-VEGF eye injections that worked, stopped them more than 3 months ago, and now have fluid in the retina shown on a scan
• Your vision in the eye being studied falls within a specific range — roughly between 20/32 and 20/400 on a standard eye chart
• There may be additional requirements set by the trial site (confirm with trial site)

Who may not be able to join:

• You have a specific type of blood vessel condition in the eye (polypoidal choroidal vasculopathy) that puts you at high risk of serious bleeding
• You have a large amount of bleeding under the retina, or significant scarring or tissue loss affecting more than half the problem area or the central part of your vision
• Your abnormal blood vessel growth is caused by something other than age-related macular degeneration
• You have any other eye condition in the study eye that could affect your vision
• You have active inflammation or infection in either eye, or a history of a specific type of eye inflammation related to the immune system (uveitis)
• You have a high level of short-sightedness (prescription stronger than -6.00)
• You had eye surgery in the study eye within the past 90 days before the screening visit
• You have previously had certain eye treatments, including a light-based therapy (photodynamic therapy) within 120 days, radiation treatment, certain types of laser treatment, macular surgery, or heat-based eye therapy
• You received certain anti-VEGF treatments given through the body (not the eye) within 90 days before starting the study
• You are pregnant or breastfeeding
• You have a known allergy or medical reason to avoid any of the study treatments or procedures
• You have had serious heart problems — such as heart failure, unstable chest pain, a heart attack, a stroke-like heart event, a blood clot, or a major bleeding episode — within the past 6 months, or you have high blood pressure that is not well controlled, or a heart rhythm problem requiring ongoing treatment
• You had a stroke within the past 12 months, or a mini-stroke (transient ischemic attack) within the past 6 months
• You have poorly controlled diabetes, indicated by a blood sugar level measure (HbA1c) of 12% or higher
• There may be additional reasons set by the trial site that could affect eligibility (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.