Lymphoma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 14 and 80 years old.
• People with a confirmed diagnosis of B-cell lymphoma affecting the central nervous system (brain or spinal cord), confirmed through tissue or fluid testing.
• People whose lymphoma has come back or has not responded to treatment, and who have received at least one previous treatment targeting the disease in the central nervous system.
• People whose life expectancy is judged by the investigating doctor to be more than 3 months.
• People whose side effects from previous treatments have mostly resolved to a mild or normal level (hair loss is an exception and does not need to have resolved).
• People whose blood counts, liver, kidney, and clotting function meet certain minimum levels as measured by blood tests, without having needed blood transfusions, growth factor injections, or corrective medications in the 14 days before screening (confirm with trial site for specific values).
• People who are willing and able to follow all trial schedules, appointments, and procedures.
• People who are willing to use effective contraception throughout the trial and for 3 months after treatment ends, if there is any possibility of becoming pregnant or fathering a child. Male participants must also avoid sperm donation during this period.
• People who fully understand the trial and agree to take part by signing a consent form (or whose legal guardian signs on their behalf).

Who may not be able to join:

• People who have a known allergy or medical reason preventing them from taking any of the drugs used in this trial.
• People with a history of active liver disease, including active hepatitis B (based on virus levels in the blood), cirrhosis, or active hepatitis C (based on specific blood test results).
• People who have HIV infection.
• People with significant heart failure, or who have had a heart attack, unstable chest pain, stroke, or mini-stroke in the past six months.
• People with a hereditary condition causing abnormal heart rhythm, or whose heart rhythm measurement (QTc interval) is above a certain level on an electrocardiogram.
• People who are pregnant, breastfeeding, or planning to become pregnant during the trial period.
• People with a significant history of neurological or psychiatric conditions, or a history of abusing certain medications or substances.
• People with a clinically significant active infection at the time of joining.

Important: Always verify eligibility with the trial site directly before applying.