Phase 2 Schizophrenia Trial, Recruiting NCT07191483 Sponsor: Kynexis B.V. Condition: Schizophrenia
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Phase 2 Schizophrenia Trial, Recruiting

NCT07191483
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been formally diagnosed with schizophrenia as their primary psychiatric condition
  • People whose schizophrenia has been in a stable, non-crisis phase for at least 8 weeks before the screening appointment, as judged by the study doctor
  • People who have had a schizophrenia diagnosis for at least 1 year before the screening appointment
  • People who have been taking a single antipsychotic medication (with any additional mental health medications) at the same stable dose for at least 2 months before screening
  • People aged between 18 and 55 years old (male or female)
  • People whose body weight falls within a healthy range, specifically a Body Mass Index (BMI) between 18 and 40 (confirm with trial site if unsure how to calculate this)
  • People who the study doctor believes are able to follow all study procedures throughout the trial
  • People who have read, understood, and signed a consent form before the screening process begins

Who may not be able to join:

  • People who are currently being treated with more than one antipsychotic medication at the time of screening
  • People who show certain movement-related side effects, measured by a standard rating scale called the Modified Simpson-Angus Scale, scoring 2 or higher on any individual item at screening (confirm with trial site)
  • People who have a moderate to severe problem with substance use — this includes alcohol, but does not include nicotine or caffeine
  • People who have an unstable or poorly controlled physical health condition

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 19 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Sponsor
Kynexis B.V.
Registry
ClinicalTrials.gov
Start date
27 August 2025
Est. completion
1 October 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

To evaluate the efficacy of KYN-5356 treatment on cognitive function in adults with cognitive impairment associated with schizophrenia (CIAS)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 19 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov