Schizophrenia Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
For people with a first episode of psychosis (Studies 1a and 1b):
- People aged 18 to 55 years old
- People who are able to understand the study and are willing to sign a consent form
- People who are fluent in English, as all tasks and questionnaires are in English
- People who have been diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder, or severe depression with psychosis, where the psychosis has been present for less than 5 years in total
- People whose condition has been stable on treatment for at least 8 weeks
- People who are able to travel to the University of Nottingham for in-person visits
For healthy volunteers (Studies 1a and 1b):
- People aged 18 to 55 years old
- People who are able to understand the study and are willing to sign a consent form
- People who are fluent in English or speak it as a first language
- People who are able to travel to the University of Nottingham for in-person visits
For people with lived experience of psychosis (Study 2):
- People aged 18 years or older
- People who are able to understand the study and are willing to sign a consent form
- People who are fluent in English
- People who have a personal diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder, or severe depression with psychosis — there is no time limit on when the first episode occurred
- People whose condition has been stable on treatment for at least 8 weeks
- People who are able to travel to the University of Nottingham for in-person visits
Who may not be able to join:
For people with a first episode of psychosis (Studies 1a and 1b):
- People with a significant neurological condition or another major psychiatric condition alongside their psychosis, in the opinion of the research team
- People with a history of a significant head injury
- People who are currently misusing or are dependent on substances such as alcohol or drugs (not including nicotine), in the opinion of the research team
- People currently taking medication that may affect the brain chemicals being studied, in the opinion of the research team
- People who cannot have an MRI scan — for example, due to claustrophobia, pregnancy, or having metal implants in their body
- People who cannot receive brain stimulation (a non-invasive technique called transcranial direct current stimulation) — for example, due to having a pacemaker or other implanted device, a history of seizures or epilepsy, or an open wound on the head
- People who have taken part in a clinical trial involving a drug or invasive procedure within the past month
For healthy volunteers (Studies 1a and 1b):
- People with a personal or family history of psychosis
- People with a significant neurological or psychiatric condition
- People with a history of a significant head injury
- People who are currently misusing or are dependent on substances such as alcohol or drugs (not including nicotine or caffeine), in the opinion of the research team
- People currently taking medication that may affect the brain chemicals being studied, in the opinion of the research team
- People who cannot have an MRI scan — for example, due to claustrophobia or pregnancy
- People who cannot receive transcranial direct current stimulation — for example, due to having a pacemaker or other implanted device, a history of seizures or epilepsy, or an open wound on the head
- People who have taken part in a clinical trial involving a drug, payment as a participant, or an invasive procedure within the past month
For people with lived experience of psychosis (Study 2):
- People with a significant neurological condition or another major psychiatric condition alongside their psychosis
- People who are currently misusing or are dependent on substances such as alcohol or drugs (not including nicotine), in the opinion of the research team
- People who have taken part in a clinical trial involving a drug or invasive procedure within the past month
- People whose connection to psychosis is through supporting or caring for someone else, rather than having personally experienced psychosis symptoms themselves
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Claudia Danielmeier, PhD, University of Nottingham
Phone: +44 115 84 66360
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Measures of glutamate and GABA change (quantified using fMRS) during a working memory task; Correlation between glutamate and GABA responses during a WM task and tDCS outcome (accuracy); Correlation between glutamate and GABA responses during a WM task and tDCS outcome (reaction time); Qualitative data analysis: Perceived cognitive impairments in psychosis; Qualitative data analysis: Expectations and concerns around interventions that involve brain scanning and brain stimulation
Can't join this trial?
Data last synced from ClinicalTrials.gov: 22 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.