Phase 3 Stroke Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- Adults aged 18 or older, of any gender
- People whose stroke symptoms began between 4.5 and 24 hours before treatment — this includes people who woke up with stroke symptoms or had a stroke with no one present to witness it; the starting time is counted from the last moment the person was known to be well
- People who were largely independent before the stroke (a low disability score of 0 or 1 on a standard scale called the Modified Rankin Scale)
- People with a stroke severity score of 6 or higher on a standard medical scale (called the NIHSS)
- People whose brain scans (CT or MRI with specialised imaging) show a blockage in a specific brain artery, and whose scans show that a meaningful area of brain tissue is at risk but not yet permanently damaged — measured using specific size and ratio thresholds (confirm exact imaging requirements with trial site)
- People (or their legal guardian) who are willing and able to sign a consent form to participate
Who may not be able to join:
- People who have a known allergy to a clot-dissolving medication called recombinant human tissue plasminogen activator (rhTNK-tPA)
- People whose life expectancy is estimated to be less than one year
- People whose stroke symptoms are improving rapidly on their own, as judged by the medical team
- People who are significantly unresponsive or unconscious (scoring above 2 on a specific part of the NIHSS consciousness assessment), or who had a seizure at the time of the stroke, or developed limb weakness following a seizure, or have another neurological or psychiatric condition that prevents them from cooperating
- People with severely high blood pressure that cannot be controlled with medication
- People with blood sugar levels that are very low (below 2.8 mmol/L) or very high (above 22.2 mmol/L)
- People with active internal bleeding or a high risk of bleeding
- People with any known blood clotting disorder
- People with known problems with platelet function, or a platelet count below 100×10⁹/L (a measure of blood cells that help with clotting)
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Phone: 031169085587
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
The proportion of participants with a score of 0-1 on the modified Rankin Scale (mRS)
Can't join this trial?
Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.