Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been confirmed by a tissue biopsy to have a type of esophageal (food pipe) cancer called squamous cell carcinoma
• Your cancer has spread to other parts of the body or is at an advanced local stage
• You have not yet received any treatment (such as immunotherapy, chemotherapy, or radiotherapy) for this stage of your cancer
• Your cancer specialist and a doctor specialising in older adult care have decided that standard platinum-based chemotherapy is not suitable for you
• You have at least one tumour that can be measured or evaluated on a scan
• You are 70 years of age or older
• You are still able to carry out some daily activities (your general health and functioning level meets a specific medical standard — confirm with trial site)
• Your life expectancy is estimated to be more than 3 months
• If you had previous treatment after surgery (adjuvant therapy), it was completed more than 6 months ago
• Your blood counts and organ function (bone marrow, liver, kidneys) are at an acceptable level as shown by recent blood tests
• If you are male and sexually active, you are willing to use a condom during treatment and for 6 months after the last dose, particularly with a pregnant partner or a partner who could become pregnant; female partners should also use effective contraception during this period
• You are willing and able to attend all required appointments, treatments, and follow-up visits as set out in the study plan
• You have signed a consent form agreeing to take part before any study-related procedures begin
• You are covered by a social security (health insurance) scheme

Who may not be able to join:

• You have a history of another cancer, unless it was fully treated with no signs of return for at least 2 years, or it was a minor skin cancer or early-stage cancer (carcinoma in situ) that has been fully treated with no signs of disease
• Your esophageal cancer is at a stage where surgery or curative radiotherapy may still be possible, according to the local specialist
• You have taken part in another clinical trial involving an experimental treatment in the last 2 months
• You are currently enrolled in another clinical trial that involves an active treatment (observational studies or follow-up phases may be allowed — confirm with trial site)
• You have previously had an organ transplant, bone marrow transplant, or umbilical cord blood transplant from another person
• You have an active autoimmune or inflammatory condition (such as Crohn's disease, lupus, rheumatoid arthritis, or similar conditions) — although some milder conditions such as well-controlled thyroid disease, vitiligo, hair loss, or diet-controlled celiac disease may still be eligible (confirm with trial site)
• You have previously received immunotherapy drugs that target immune checkpoints within the last 2 years
• You have an uncontrolled or serious illness, including uncontrolled fluid build-up around the lungs, heart, or abdomen that needs frequent draining
• You have a connection (fistula) between your food pipe and your airway or main blood vessel (aorta)
• You have had a serious heart event such as a heart attack, blood clot, stroke, or heart failure within the last 6 months, or have other uncontrolled serious medical conditions
• You have a blood or bone marrow disorder called myelodysplastic syndrome or acute myeloid leukaemia, or show signs that may suggest these conditions
• You have cancer that has spread to your brain and is causing symptoms
• You have a primary immune deficiency condition
• You have HIV that is not well controlled, with a low immune cell count (confirm with trial site)
• You have an active infection, including active tuberculosis, untreated hepatitis B, or active hepatitis C
• You have taken immune-suppressing medication in the 14 days before starting the study treatment (with some exceptions, such as low-dose steroids, inhaled or topical steroids — confirm with trial site)
• You have received a live vaccine within 30 days before starting the study immunotherapy
• You are unable or unlikely to attend follow-up appointments, for any reason including personal, family, psychological, or geographical circumstances
• You are legally deprived of freedom, under certain forms of psychiatric care orders, or are legally unable to give your own consent to participate

Important: Always verify eligibility with the trial site directly before applying.