Phase 1 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed (confirmed by tissue testing) with an advanced form of high-grade ovarian, fallopian tube, or primary peritoneal cancer (specifically serous or endometrioid type), based on either a previous or new biopsy.
• Your cancer has stopped responding to platinum-based chemotherapy — either it came back or grew within 6 months of finishing treatment, or it continued to grow within the first 3 months of starting platinum treatment.
• Your doctors expect you to live for more than 6 months.
• You are generally well enough to carry out light activity and care for yourself (this is measured on a standard medical scale called ECOG, at level 0 or 1).
• Your cancer can be measured on scans using a standard method called RECIST v1.1.
• You have not had a bowel blockage in the past 3 months, and you have no current signs or symptoms of one.

Who may not be able to join:

• You have received any cancer treatment or experimental drug within the past 28 days (or within 5 half-lives of the drug), before starting this trial.
• You have previously been treated with a type of virus-based therapy called a group B adenovirus.
• You have had radiotherapy within the 4 weeks before starting the trial.
• You have cancer that has spread to the brain or nervous system, or you show signs of this; if you previously had brain metastases, there must be no sign of them worsening or bleeding after treatment.
• You have uncontrolled fluid build-up around the lungs or heart that needs draining at least once a month.
• You have previously had inflammation of the lungs (pneumonitis) or a chronic lung scarring condition (interstitial lung disease).
• You have a specific heart rhythm abnormality shown on a heart tracing (ECG), or a personal history of certain inherited or acquired heart rhythm conditions (confirm with trial site).
• You are currently taking medications known to affect heart rhythm in a way that could be dangerous (confirm with trial site).
• You currently have an active hepatitis C infection, or an active hepatitis B infection (people with past or resolved hepatitis B may still be eligible).
• You currently have an active tuberculosis (TB) infection.
• You currently have an active COVID-19 infection.
• You have an active HIV infection or a known history of HIV.
• You have had a serious infection requiring intravenous (IV) antibiotics within the past 2 weeks, or you are on long-term antibiotic tablets for an ongoing infection.
• You are known to be allergic or sensitive to any ingredients in the trial drug, THEO-260.
• You have an active autoimmune disease (where your immune system attacks your own body) that has needed treatment in the past 2 years.
• You have been diagnosed with moderate to severe heart failure (NYHA Class 2–4).
• You are known to be allergic or sensitive to paracetamol (acetaminophen).
• You regularly drink more than 2 units of alcohol per day.
• You have a weakened heart pump (below 45% efficiency), unstable chest pain, a serious uncontrolled heart rhythm problem, a heart attack within the past 6 months, or a history of heart muscle inflammation (myocarditis).
• Your blood oxygen level is below 92% while breathing normal room air before starting the trial.
• You have received any vaccine (approved or experimental) within the 30 days before the trial start date.

Important: Always verify eligibility with the trial site directly before applying.