Phase 1 Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You must be between 65 and 85 years old
• You must have been diagnosed with early-stage Alzheimer's Disease, confirmed by a specific brain scan that detects a protein called beta amyloid
• Your Alzheimer's must be at an early, mild stage, based on standard memory and thinking tests (scores within a specific range on tests called CDR and MMSE)
• You must not have any other type of dementia (such as Lewy Body dementia)
• If you take any medication for memory or mood, the dose must have been stable for at least 60 days, and must be a low dose (confirm with trial site)
• You must be able to give your own informed consent to participate
• You must have a caregiver who is available and willing to take part in the study with you
• You must be living at home and expected to remain at home for the whole length of the study
• You must have a low score on a depression screening test (Geriatric Depression Scale of 5 or less)
• You must not have significant thoughts of suicide, based on a standard screening questionnaire
• You must not be experiencing strong delusions, hallucinations, or agitation/aggression, based on a behaviour questionnaire

Who may not be able to join:

• You may not be eligible if you have had a serious head injury, brain tumour, bleeding around the brain, or other significant brain problems in the last 2 years
• You may not be eligible if you have a medical implant that would prevent you from having a high-powered MRI scan (confirm with trial site)
• You may not be eligible if you currently have or have a history of a major psychiatric condition such as schizophrenia, bipolar disorder, or severe depression
• You may not be eligible if you have a history of suicide attempts or suicidal crises
• You may not be eligible if you have another brain or nervous system condition, such as Parkinson's disease, stroke, or other forms of dementia
• You may not be eligible if you have a history of seizures or epilepsy
• You may not be eligible if you have a serious illness where life expectancy is less than 30 months
• You may not be eligible if you have another recognised form of dementia, such as those caused by Lewy body disease, Huntington's disease, HIV, Parkinson's disease, vascular disease, traumatic brain injury, or prion disease
• You may not be eligible if you have any unstable medical or neurological conditions, as judged by the lead doctor running the trial

Important: Always verify eligibility with the trial site directly before applying.