Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with prostate cancer (adenocarcinoma) confirmed by a tissue biopsy, at an intermediate or favorable high-risk stage (classified as stage IIA–IIC under a specific staging system)
• People aged 18 or older
• People whose general physical health and ability to carry out daily activities meets a certain minimum level (confirm with trial site)
• People whose prostate is no larger than 100cc in size, as measured by MRI or ultrasound within the past 24 months (or within 6 months if hormone therapy has been used)
• People who have had a specific type of prostate MRI scan (multiparametric MRI) showing certain findings, or a particular type of nuclear medicine scan (PSMA PET/CT), within 12 months of joining the study
• People whose urinary symptom score is 15 or below on a standard questionnaire (use of medications to help urinary flow is allowed)
• People who are able to fully understand and are willing to sign a consent form for the study

Who may not be able to join:

• People who are currently experiencing severe bowel or urinary side effects (grade 3 or higher on a standard scale)
• People who are currently taking part in another clinical trial involving an experimental treatment
• People who have previously had radiation therapy to the pelvic area
• People whose cancer has spread to the lymph nodes
• People whose cancer has been found to have grown outside the prostate on MRI (scanned within the past 24 months, or before hormone therapy began if hormone therapy was used)
• People who have previously had procedures that destroy prostate tissue, such as cryotherapy, HIFU, or nanoknife treatment
• People who have previously had a full surgical removal of the prostate (simple prostatectomy) — however, people who have had certain other prostate procedures (TURP or laser enucleation) may still be eligible
• People currently receiving other cancer-fighting drugs, including methotrexate — however, people who have previously received hormone therapy (ADT) may still be eligible if the total course was less than 6 months, the last dose was more than 6 months ago, and hormone levels have recovered to a certain level (confirm with trial site)
• People who have another serious uncontrolled health condition, such as an active infection, unstable heart condition, uncontrolled heart rhythm problems, or a mental health or social situation that would make it difficult to follow the study requirements
• People with any other condition that their treating doctor considers makes it unsafe to receive the radiation treatment used in this trial
• People with active inflammatory bowel disease or an active connective tissue disorder affecting blood vessels
• People who are unable to have small marker seeds (fiducials) placed in the prostate
• People who are unable to have a spacer device placed between the prostate and rectum (people with an iodine allergy who can only receive a non-contrast spacer may still be eligible)
• People who are unable to have a prostate MRI scan
• People with artificial hip replacements on both sides — people with a replacement on one side only may be eligible if the radiation treatment plan meets all required safety limits (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.